RT Journal Article
T1 Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis
A1 Rapado Castro, Marta
A1 Villar Arenzana, Mara
A1 Janssen, Joost
A1 Fraguas Herráez, David
A1 Bombin, Igor
A1 Castro Fornieles, Josefina
A1 González Pinto, Ana
A1 Serna, Elena de la
A1 Mayoral Muñoz, María José
A1 Parellada, Mara
A1 Paya, Beatriz
A1 Moreno Pardillo, Dolores María
A1 Graell, Montserrat
A1 Baeza, Inmaculada
A1 Pantelis, Christos
A1 Arango López, Celso
AB Cognitive maturation during adolescence is modulated by brain maturation. However, it is unknown how these processes intertwine in early onset psychosis (EOP). Studies examining longitudinal brain changes and cognitive performance in psychosis lend support for an altered development of high-order cognitive functions, which parallels progressive gray matter (GM) loss over time, particularly in fronto-parietal brain regions. We aimed to assess this relationship in a subsample of 33 adolescents with first-episode EOP and 47 matched controls over 2 years. Backwards stepwise regression analyses were conducted to determine the association and predictive value of longitudinal brain changes over cognitive performance within each group. Fronto-parietal GM volume loss was positively associated with decreased working memory in adolescents with psychosis (frontal left (B = 0.096, p = 0.008); right (B = 0.089, p = 0.015); parietal left (B = 0.119, p = 0.007), right (B = 0.125, p = 0.015)) as a function of age. A particular decrease in frontal left GM volume best predicted a significant amount (22.28%) of the variance of decreased working memory performance over time, accounting for variance in age (14.9%). No such association was found in controls. Our results suggest that during adolescence, EOP individuals seem to follow an abnormal neurodevelopmental trajectory, in which fronto-parietal GM volume reduction is associated with the differential age-related working memory dysfunction in this group.
PB MPDI
SN 2077-0383
YR 2021
FD 2021-08-31
LK https://hdl.handle.net/20.500.14352/4792
UL https://hdl.handle.net/20.500.14352/4792
LA eng
NO Rapado Castro, M., Villar Arenzana, M., Janssen, J. et al. «Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis». Journal of Clinical Medicine, vol. 10, n.o 17, agosto de 2021, p. 3929. DOI.org (Crossref), https://doi.org/10.3390/jcm10173929.
NO Unión Europea
NO Ministerio de Ciencia, Innovación y Universidades (España)/Instituto de Salud Carlos III
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Comunidad de Madrid
NO Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional
DS Docta Complutense
RD 7 abr 2025