RT Journal Article
T1 Metallic Nanoparticles—friends or foes in the battle against antibiotic-Resistant Bacteria?
A1 Amaro Torres, Francisco
A1 Morón García, Álvaro
A1 Díaz del Toro, Silvia
A1 Martín González, Ana María
A1 Gutiérrez Fernández, Juan Carlos
AB The rapid spread of antibiotic resistances among bacteria demands novel strategies for infection control, and metallic nanoparticles appear as promising tools because of their unique size and tunable properties that allow their antibacterial effects to be maximized. Furthermore, their diverse mechanisms of action towards multiple cell components have suggested that bacteria could not easily develop resistance against nanoparticles. However, research published over the last decade has proven that bacteria can indeed evolve stable resistance mechanisms upon continuous exposure to metallic nanoparticles. In this review, we summarize the currently known individual and collective strategies employed by bacteria to cope with metallic nanoparticles. Importantly, we also discuss the adverse side effects that bacterial exposure to nanoparticles may have on antibiotic resistance dissemination and that might constitute a challenge for the implementation of nanoparticles as antibacterial agents. Overall, studies discussed in this review point out that careful management of these very promising antimicrobials is necessary to preserve their efficacy for infection control.
PB MDPI
SN Electronic: 2076-2607
YR 2021
FD 2021-02-12
LK https://hdl.handle.net/20.500.14352/8192
UL https://hdl.handle.net/20.500.14352/8192
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 24 ago 2024