RT Journal Article
T1 Synthesis of Glycodendrimers with Antiviral and Antibacterial Activity
A1 Hoyos Vidal, María Pilar
A1 Juanes, Olga
A1 Perona Requena, Almudena
A1 Rumbero, Ángel
A1 Hernáiz Gómez-Degano, María Josefa
AB Glycodendrimers are an important class of synthetic macromolecules that can be used to mimic many structural and functional features of cell‐surface glycoconjugates. Their carbohydrate moieties perform key important functions in bacterial and viral infections, often regulated by carbohydrate–protein interactions. Several studies have shown that the molecular structure, valency and spatial organisation of carbohydrate epitopes in glycoconjugates are key factors in the specificity and avidity of carbohydrate–protein interactions. Choosing the right glycodendrimers almost always helps to interfere with such interactions and blocks bacterial or viral adhesion and entry into host cells as an effective strategy to inhibit bacterial or viral infections. Herein, the state of the art in the design and synthesis of glycodendrimers employed for the development of anti‐adhesion therapy against bacterial and viral infections is described.
PB Wiley-Blackwell
SN 0947-6539
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/96513
UL https://hdl.handle.net/20.500.14352/96513
LA eng
NO Hoyos P, Perona A, Juanes O, Rumbero Á, Hernáiz MJ. Synthesis of Glycodendrimers with Antiviral and Antibacterial Activity. Chemistry A European J 2021;27:7593–624. https://doi.org/10.1002/chem.202005065.
NO Ministerio de Ciencia, Innovación y Universidades (España)
DS Docta Complutense
RD 7 jul 2025