RT Journal Article
T1 A comparison study of cognitive deficits in radiologically and clinically isolated syndromes
A1 Labiano-Fontcuberta, Andrés
A1 Martínez-Ginés, M Luisa
A1 Aladro, Yolanda
A1 Ayuso, Lucía
A1 Mitchell, Alex J
A1 Puertas-Martín, Verónica
A1 Cerezo García, Marta
A1 Higueras Hernández, Yolanda
A1 Benito León, Julián
AB Up until now, no information has existed regarding a comparison of the pattern and frequency of cognitive deficits between radiologically isolated syndrome (RIS) and clinically isolated syndrome (CIS) patients. Within this objective, Rao's Brief Repeatable Battery and Stroop test were administered to 28 RIS patients, 25 CIS patients, and 22 healthy controls. Conclusions: The prevalence of cognitive deficits in RIS was similar to that of CIS. Cognitive deficits seem to be present in RIS patients regardless of the presence of risk factors for a future symptomatic demyelinating event.
PB Sage
SN 1477-0970
YR 2016
FD 2016-02
LK https://hdl.handle.net/20.500.14352/132694
UL https://hdl.handle.net/20.500.14352/132694
LA eng
NO Labiano-Fontcuberta, A., Martínez-Ginés, M. L., Aladro, Y., Ayuso, L., Mitchell, A. J., Puertas-Martín, V., Cerezo, M., Higueras, Y., & Benito-León, J. (2016). A comparison study of cognitive deficits in radiologically and clinically isolated syndromes. Multiple Sclerosis, 22(2), 250-253. https://doi.org/10.1177/1352458515591072
NO Dr Benito-Leon is supported by the National Institutes of Health, Bethesda, MD, USA (NINDS #R01 NS39422), the Commission of the European Union (grant ICT-2011-287739, NeuroTREMOR), and the Spanish Health Research Agency (grant FIS PI12/01602).Referencias bibliográficas:•	Lebrun C, Blanc F, Brassat D, et al. Cognitive function in radiologically isolated syndrome. Mult Scler 2010; 16: 919-925.•	Amato MP, Hakiki B, Goretti B, et al. Association of MRI metrics and cognitive impairment in radiologically isolated syndromes. Neurology 2012; 78: 309-314.•	Okuda DT, Mowry EM, Beheshtian A, et al. Incidental MRI anomalies suggestive of multiple sclerosis: The radiologically isolated syndrome. Neurology 2009; 72: 800-805.•	Swanton JK, Fernando K, Dalton CM, et al. Modification of MRI criteria for multiple sclerosis in patients with clinically isolated syndromes. J Neurol Neurosurg Psychiatry 2006; 77: 830-833.•	Rao SM, Leo GJ, Bernardin L, et al. Cognitive dysfunction in multiple sclerosis. I.Frequency, patterns, and prediction. Neurology 1991; 41: 685-691.•	Bondi MW, Serody AB, Chan AS, et al. Cognitive and neuropathologic correlates of Stroop Color-Word Test performance in Alzheimer's disease. Neuropsychology 2002; 16: 335-343.•	Hamilton M., A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56-62.•	Martínez-Martín P, Catalán MJ, Benito-León J, et al. Impact of fatigue in Parkinson's disease: The Fatigue Impact Scale for Daily Use (D-FIS). Qual Life Res 2006; 15: 597-606.•	Benito-León J, Martínez-Martín P, Frades B, et al. Impact of fatigue in multiple sclerosis: The Fatigue Impact Scale for Daily Use (D-FIS). Mult Scler 2007; 13: 645-651.•	Zipoli V, Goretti B, Hakiki B, et al. Cognitive impairment predicts conversion to multiple sclerosis in clinically isolated syndromes. Mult Scler 2010; 16: 62-67.
NO National Institute of Neurological Disorders and Stroke (NINDS)
NO European Union (EU)
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 27 feb 2026