RT Journal Article
T1 Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS‐CoV‐2
A1 Ferrer García, María Desamparados
A1 Sánchez Barrueco, Álvaro
A1 Martinez‐Beneyto, Yolanda
A1 Mateos Moreno, María Victoria
A1 Ausina-Márquez, Verónica
A1 García-Vázquez, Elisa
A1 Puche-Torres, Miguel
A1 Forner Giner, María J
A1 Campos González, Alfonso
A1 Santillán Coello, Jessica M
A1 Alcalá Rueda, Ignacio
A1 Villacampa Aubá, José M
A1 Cenjor Español, Carlos
A1 López Velasco, Ana
A1 Santolaya Abad, Diego
A1 García‐Esteban, Sandra
A1 Artacho, Alejandro
A1 López‐Labrador, Xavier
A1 Mira, A
AB Most public health measures to contain the COVID-19 pandemic are based on preventing the pathogen spread, and the use of oral antiseptics has been proposed as a strategy to reduce transmission risk. The aim of this manuscript is to test the efficacy of mouthwashes to reduce salivary viral load in vivo. This is a multi-centre, blinded, parallel-group, placebo-controlled randomised clinical trial that tests the effect of four mouthwashes (cetylpyridinium chloride, chlorhexidine, povidone-iodine and hydrogen peroxide) in SARS-CoV-2 salivary load measured by qPCR at baseline and 30, 60 and 120 min after the mouthrinse. A fifth group of patients used distilled water mouthrinse as a control. Eighty-four participants were recruited and divided into 12-15 per group. There were no statistically significant changes in salivary viral load after the use of the different mouthwashes. Although oral antiseptics have shown virucidal effects in vitro, our data show that salivary viral load in COVID-19 patients was not affected by the tested treatments. This could reflect that those mouthwashes are not effective in vivo, or that viral particles are not infective but viral RNA is still detected by PCR. Viral infectivity studies after the use of mouthwashes are therefore required. ( https://clinicaltrials.gov/ct2/show/NCT04707742 ; Identifier: NCT04707742).
PB Nature
YR 2021
FD 2021-12-22
LK https://hdl.handle.net/20.500.14352/117292
UL https://hdl.handle.net/20.500.14352/117292
LA eng
NO Ferrer MD, Barrueco ÁS, Martinez-Beneyto Y, Mateos-Moreno MV, Ausina-Márquez V, García-Vázquez E, Puche-Torres M, Giner MJF, González AC, Coello JMS, Rueda IA, Aubá JMV, Español CC, Velasco AL, Abad DS, García-Esteban S, Artacho A, López-Labrador X, Mira A. Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2. Sci Rep. 2021 Dec 22;11(1):24392. doi: 10.1038/s41598-021-03461-y
DS Docta Complutense
RD 11 abr 2025