%0 Journal Article %A Viso Beronda, Alma %A Fernández de la Pradilla Sainz de Aja, Roberto %A Flores Aguilar-Amat, Aída %T Highly diastereoselective Staudinger reaction on 5,6-dihydropyrazin-2-(1H)-ones. Synthesis of enantiopure fused oxopiperazino-β-lactams %D 2006 %U https://hdl.handle.net/20.500.14352/99180 %X The highly diastereoselective synthesis of fused oxopiperazino-β-lactams 2 by Staudinger reaction between functionalized ketenes and 5,6-dihydropyrazin-2(1H)-ones 1 has been carried out. Further cleavage of the β-lactam ring produced 2-oxopiperazine-3-acetic acid derivatives 7 with no epimerization and in good yields. %~