RT Journal Article
T1 Left Ventricular Assist Device as a Destination Therapy: Current Situation and the Importance of Patient Selection
A1 Melendo-Viu, María
A1 Dobarro Pérez, David
A1 Raposeiras Roubin, Sergio
A1 Llamas Pernas, Carmen
A1 Moliz Cordón, Candela
A1 Vázquez Lamas, Miriam
A1 Piñón Esteban, Miguel
A1 Varela Martínez, María Ángela
A1 Abu Assi, Emad
A1 Pita Romero, Rafael
A1 Legarra Calderón, Juan José
A1 Íñiguez Romo, Andrés
AB Advanced heart failure is a growing problem for which the best treatment is cardiac transplantation. However, the shortage of donors’ hearts made left ventricular assist devices as destination therapy (DT-LVAD) a highly recommended alternative: they improved mid-term prognosis as well as patients’ quality of life. Current intracorporeal pumps with a centrifugal continuous flow evolved in the last few years. Since 2003, when first LVAD was approved for long-term support, smaller device sizes with better survival and hemocompatibility profile were reached. The most important difficulty lies in the moment of the implant. Recent indications range from INTERMACS class 2 to 4, with close monitoring in intermediate cases. Moreover, a large multiparametric study is needed for considering the candidacy: basal situation, with a special interest in frailty, comorbidities, including renal and hepatic dysfunction, and medical background, considering every prior cardiac condition, must be evaluated. In addition, some clinical risk scores can be helpful to measure the possibility of right heart failure or morbi-mortality. With this review, we sought to summarize all the device improvements, with their updated clinical results, as well as to focus on all the patient selection criteria.
PB MDPI
YR 2023
FD 2023-04-21
LK https://hdl.handle.net/20.500.14352/104902
UL https://hdl.handle.net/20.500.14352/104902
LA eng
NO Melendo-Viu M, Dobarro D, Raposeiras Roubin S, Llamas Pernas C, Moliz Cordón C, Vazquez Lamas M, et al. Left Ventricular Assist Device as a Destination Therapy: Current Situation and the Importance of Patient Selection. Life 2023;13:1065. https://doi.org/10.3390/life13041065.
NO 2023 Descuento MDPI
DS Docta Complutense
RD 26 abr 2025