RT Journal Article
T1 Accuracy of MRI criteria for dissemination in space for the diagnosis of multiple sclerosis in patients with clinically isolated syndromes
A1 Díaz-Sánchez Marıía, 
A1 Gómez-Moreno Mayra, 
A1 Morales-Otal Asunción, 
A1 Ramos González, Ana
A1 Benito León, Julián
AB The MRI Barkhof–Tintore´ criteria have proved to be highly specific for predicting conversion to clinically definite multiplesclerosis in patients with clinically isolated syndromes (CIS), but lacked an optimal sensitivity. In order to improve theaccuracy of early multiple sclerosis diagnosis, new imaging criteria have been proposed by Swanton et al. We aimed toevaluate the accuracy of both MRI criteria for dissemination in space to predict conversion from CIS to clinically definitemultiple sclerosis. We studied 79 CIS patients with baseline MRI performed within the first 3 months after onset. Thesensitivity and specificity of both MRI criteria to predict conversion to clinically definite multiple sclerosis were analysed.The time to develop clinically definite multiple sclerosis from CIS onset, according to each imaging criteria, was studiedby Kaplan–Meier survival curves. The overall conversion rate was 75.7% with a median follow-up of 57 months. Barkhof–Tintore´’s criteria showed a sensitivity of 71.9% and a specificity of 77.2%. Swanton’s criteria had a sensitivity of 91.2% anda specificity of 68.1%. Both MRI criteria identified CIS patients with higher risk and faster conversion to clinically definitemultiple sclerosis. Swanton’s criteria are simpler and more sensitive than Barkhof–Tintore´‘s criteria, with a slightdecrease in specificity. These results reinforce their use in multiple sclerosis diagnosis.
PB Sage
YR 2010
FD 2010
LK https://hdl.handle.net/20.500.14352/116662
UL https://hdl.handle.net/20.500.14352/116662
LA eng
NO Díaz-Sánchez M, Mayra Gómez-Moreno S, Asunción Morales-Otal M, Ramos-González A, Benito-León J. Accuracy of MRI criteria for dissemination in space for the diagnosis of multiple sclerosis in patients with clinically isolated syndromes. Mult Scler. 2010 May;16(5):576-80
DS Docta Complutense
RD 7 abr 2025