RT Journal Article
T1 A pan-cancer analysis of tumor-infiltrating B cell repertoires
A1 Yu, Katharine
A1 Ravoor, Akshay
A1 Malats, Núria
A1 Pineda Sanjuan, Silvia
A1 Sirota, Marina
A2 Hojjat-Farsangi, Mohammad
AB Tumor-infiltrating B cells can play an important role in anti-tumor responses but their presence is not well understood. In this study, we extracted the B cell receptor repertoires from 9522 tumor and adjacent non-tumor samples across 28 tumor types in the Cancer Genome Atlas project and performed diversity and network analysis. We identified differences in diversity and network statistics across tumor types and subtypes and observed a trend towards increased clonality in primary tumors compared to adjacent non-tumor tissues. We also found significant associations between the repertoire features and mutation load, tumor stage, and age. Our V-gene usage analysis identified similar V-gene usage patterns in colorectal and endometrial cancers. Lastly, we evaluated the prognostic value of the repertoire features and identified significant associations with survival in seven tumor types. This study warrants further research into better understanding the role of tumor-infiltrating B cells across a wide range of tumor types.
SN 1664-3224
YR 2022
FD 2022-01-05
LK https://hdl.handle.net/20.500.14352/102399
UL https://hdl.handle.net/20.500.14352/102399
LA eng
NO Yu, K., Ravoor, A., Malats, N., Pineda, S., & Sirota, M. (2021). A pan-cancer analysis of tumor-infiltrating b cell repertoires. Frontiers in Immunology, 12, 790119–790119.
NO The supplementary material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2021.790119/full#supplementary-material
NO 2019 AACR-AstraZeneca Immuno-oncology Research Fellowship
DS Docta Complutense
RD 30 jul 2025