RT Journal Article
T1 Alpha band disruption in the AD-continuum starts in the Subjective Cognitive Decline stage: a MEG study
A1 López Sanz, David
A1 Bruña Fernández, Ricardo
A1 Garcés, P.
A1 Camara, C.
A1 Serrano Martínez, Noelia
A1 Rodríguez Rojo, Inmaculada Concepción
A1 Delgado Losada, María Luisa
A1 Montenegro Peña, María Mercedes
A1 López Sánchez, Ramón
A1 Yus, M.
A1 Maestu Unturbe, Fernando
AB The consideration of Subjective Cognitive Decline (SCD) as a preclinical stage of AD remains still a matter of debate. Alpha band alterations represent one of the most significant changes in the electrophysiological profile of AD. In particular, AD patients exhibit reduced alpha relative power and frequency. We used alpha band activity measured with MEG to study whether SCD and MCI elders present these electrophysiological changes characteristic of AD, and to determine the evolution of the observed alterations across AD spectrum. The total sample consisted of 131 participants: 39 elders without SCD, 41 elders with SCD and 51 MCI patients. All of them underwent MEG and MRI scans and neuropsychological assessment. SCD and MCI patients exhibited a similar reduction in alpha band activity compared with the no SCD group. However, only MCI patients showed a slowing in their alpha peak frequency compared with both SCD and no SCD. These changes in alpha band were related to worse cognition. Our results suggest that AD-related alterations may start in the SCD stage, with a reduction in alpha relative power. It is later, in the MCI stage, where the slowing of the spectral profile takes place, giving rise to objective deficits in cognitive functioning.
PB Nature
SN 2045-2322
YR 2016
FD 2016-11-24
LK https://hdl.handle.net/20.500.14352/93637
UL https://hdl.handle.net/20.500.14352/93637
LA eng
NO López-Sanz, D. et al. Alpha band disruption in the AD-continuum starts in the Subjective Cognitive Decline stage: a MEG study. Sci. Rep. 6, 37685; doi: 10.1038/srep37685 (2016)
DS Docta Complutense
RD 10 abr 2025