RT Journal Article
T1 Clinical Factors Associated with Reinfection versus Relapse in Infective Endocarditis: Prospective Cohort Study
A1 Calderón Parra, Jorge
A1 Kestler Hernández, Martha
A1 Ramos Martínez, Antonio
A1 Bouza, Emilio
A1 Valerio Minero, Maricela
A1 Alarcón, Arístides
A1 Luque Pérez, Rafael
A1 Goenaga, Miguel
A1 Echeverría, Tomás
A1 Fariñas, María del Carmen
A1 Pericàs, Juan
A1 Ojeda Burgos, Guillermo
A1 Fernández Cruz, Ana
A1 Plata, Antonio
A1 Vinuesa, David
A1 Muñoz, Patricia
AB We aimed to identify clinical factors associated with recurrent infective endocarditis (IE) episodes. The clinical characteristics of 2816 consecutive patients with definite IE (January 2008–2018) were compared according to the development of a second episode of IE. A total of 2152 out of 2282 (94.3%) patients, who were discharged alive and followed-up for at least the first year, presented a single episode of IE, whereas 130 patients (5.7%) presented a recurrence; 70 cases (53.8%) were due to other microorganisms (reinfection), and 60 cases (46.2%) were due to the same microorganism causing the first episode. Thirty-eight patients (29.2%), whose recurrence was due to the same microorganism, were diagnosed during the first 6 months of follow-up and were considered relapses. Relapses were associated with nosocomial endocarditis (OR: 2.67 (95% CI: 1.37–5.29)), enterococci (OR: 3.01 (95% CI: 1.51–6.01)), persistent bacteremia (OR: 2.37 (95% CI: 1.05–5.36)), and surgical treatment (OR: 0.23 (0.1–0.53)). On the other hand, episodes of reinfection were more common in patients with chronic liver disease (OR: 3.1 (95% CI: 1.65–5.83)) and prosthetic endocarditis (OR: 1.71 (95% CI: 1.04–2.82)). The clinical factors associated with reinfection and relapse in patients with IE appear to be different. A better understanding of these factors would allow the development of more effective therapeutic strategies.
PB MPDI
SN 2077-0383
YR 2021
FD 2021-02-08
LK https://hdl.handle.net/20.500.14352/6959
UL https://hdl.handle.net/20.500.14352/6959
LA eng
DS Docta Complutense
RD 29 abr 2025