RT Journal Article
T1 Glucocorticoid Signaling in Myeloid Cells Worsens Acute CNS Injury and Inflammation
A1 Sorrells, Shawn
A1 Caso Fernández, Javier Rubén
A1 Munhoz, Carolina
A1 Hu, Caroline
A1 Tran, Kevin
A1 Miguel, Zurine
A1 Chien, Bonnie
A1 Sapolsky, Robert
AB Glucocorticoid stress hormones (GCs) are well known for being anti-inflammatory, but some reports suggest that GCs can also augment aspects of inflammation during acute brain injury. Because the GC receptor (GR) is ubiquitously expressed throughout the brain, it is difficult to know which cell types might mediate these unusual “proinflammatory” GC actions. We examined this with cell type-specific deletion or overexpression of GR in mice experiencing seizure or ischemia. Counter to their classical anti-inflammatory actions, GR signaling in myeloid cells increased Iba-1 and CD68 staining as well as nuclear p65 levels in the injured tissue. GCs also reduced levels of occludin, claudin 5, and caveolin 1, proteins central to blood–brain-barrier integrity; these effects required GR in endothelial cells. Finally, GCs compromised neuron survival, an effect mediated by GR in myeloid and endothelial cells to a greater extent than by neuronal GR.
PB Society for Neuroscience
SN 1529-2401
YR 2013
FD 2013-03-25
LK https://hdl.handle.net/20.500.14352/134346
UL https://hdl.handle.net/20.500.14352/134346
LA eng
NO Sorrells, S. F., Caso, J. R., Munhoz, C. D., Hu, C. K., Tran, K. V., Miguel, Z. D., Chien, B. Y., & Sapolsky, R. M. (2013). Glucocorticoid signaling in myeloid cells worsens acute CNS injury and inflammation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(18), 7877–7889. https://doi.org/10.1523/JNEUROSCI.4705-12.2013
DS Docta Complutense
RD 9 abr 2026