RT Journal Article
T1 Concanavalin A-targeted mesoporous silica nanoparticles for infection treatment.
A1 Martínez Carmona, Marina
A1 Izquierdo Barba, Isabel
A1 Colilla Nieto, Montserrat
A1 Vallet Regí, María Dulce Nombre
AB The ability of bacteria to form biofilms hinders any conventional treatment for chronic infections and has serious socio-economic implications. For this purpose, a nanocarrier capable of overcoming the barrier of the mucopolysaccharide matrix of the biofilm and releasing its loadedantibiotic within this matrix would be desirable. Herein, we developed a new nanosystem based on levofloxacin (LEVO)-loaded mesoporous silica nanoparticles (MSNs) decorated with the lectin concanavalin A (ConA). The presence of ConA promotes the internalization of this nanosystem into the biofilm matrix, which increases the antimicrobial efficacy of the antibiotic hosted within the mesopores. This nanodevice is envisioned as a promising alternative to conventional treatments for infection by improving the antimicrobial efficacy and reducing side effects.
PB Elsevier
SN 1742-7061
YR 2019
FD 2019-07-03
LK https://hdl.handle.net/20.500.14352/13447
UL https://hdl.handle.net/20.500.14352/13447
LA eng
NO RESEARCHER ID N-3992-2014 (Marina Martínez Carmona)ORCID 0000-0002-2026-6266 (Marina Martínez Carmona)RESEARCHER ID M-9921-2014 (Isabel Izquierdo Barba)ORCID 0000-0002-4139-4646 (Isabel Izquierdo Barba)RESEARCHER ID N-4628-2014 (Montse Colilla Nieto)ORCID 0000-0003-1961-4160 (Montse Colilla Nieto)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. Horizonte 2020
DS Docta Complutense
RD 22 mar 2025