RT Journal Article
T1 Fat: Quality, or Quantity? What Matters Most for theProgression of Metabolic Associated Fatty LiverDisease (MAFLD)
A1 Estévez-Vázquez, Olga
A1 Benedé-Ubieto, Raquel
A1 Guo, Feifei
A1 Gómez-Santos, Beatriz
A1 Aspichueta, Patricia
A1 Reissing, Johanna
A1 Bruns, Tony
A1 Sanz-García, Carlos
A1 Sydor, Svenja
A1 Bechmann, Lars P
A1 Maranillo Alcaide, Eva
A1 Sañudo Tejero, José Ramón
A1 Vázquez Osorio, María Teresa
A1 Lamas-Paz, Arantza
A1 Morán, Laura
A1 Mazariegos, Marina S
A1 Ciudin, Andreea
A1 Pericàs, Juan M.
A1 Peligros, María Isabel
A1 Vaquero, Javier
A1 Martínez-Naves, Eduardo
A1 Liedtke, Christian
A1 Regueiro González-Barros, José Ramón
A1 Trautwein, Christian
A1 Bañares Cañizares, Rafael
A1 Cubero Palero, Francisco Javier
A1 Nevzorova, Yulia A.
AB Objectives: Lately, many countries have restricted or even banned transfat, and palm oil has become a preferred replacement for food manufacturers. Whether palm oil is potentially an unhealthy food mainly due to its high content of saturated Palmitic Acid (PA) is a matter of debate. The aim of this study was to test whether qualitative aspects of diet such as levels of PA and the fat source are risk factors for Metabolic Syndrome (MS) and Metabolic Associated Fatty Liver Disease (MAFLD). Methods: C57BL/6 male mice were fed for 14 weeks with three types of Western diet (WD): 1. LP-WD—low concentration of PA (main fat source—corn and soybean oils); 2. HP-WD—high concentration of PA (main fat source—palm oil); 3. HP-Trans-WD—high concentration of PA (mainly transfat). Results: All types of WD caused weight gain, adipocyte enlargement, hepatomegaly, lipid metabolism alterations, and steatohepatitis. Feeding with HP diets led to more prominent obesity, hypercholesterolemia, stronger hepatic injury, and fibrosis. Only the feeding with HP-Trans-WD resulted in glucose intolerance and elevation of serum transaminases. Brief withdrawal of WDs reversed MS and signs of MAFLD. However, mild hepatic inflammation was still detectable in HP groups. Conclusions: HP and HP-Trans-WD play a crucial role in the genesis of MS and MAFLD.
PB MDPI
SN Electronic 2227-9059
YR 2021
FD 2021-09-22
LK https://hdl.handle.net/20.500.14352/4884
UL https://hdl.handle.net/20.500.14352/4884
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Ministerio de Ciencia, Innovación y Universidades/Fondo Regional Europeo de Desarrollo Regional (FEDER
NO Programa Ramón y Cajal
NO Comunidad de Madrid
NO COST Action
NO Universidad Complutense de Madrid (UCM), UCM/Banco de Santander
NO Gilead Liver Research Scholar
NO German Research Foundation
NO Sistema Universitario Vasco
NO Chinese Scholarship Council (CSC)
DS Docta Complutense
RD 20 ago 2024