RT Journal Article
T1 Discongruence index: Simple indicator to predict prosthesis-patient mismatch after transcatheter aortic valve replacement
A1 Islas, Fabian
A1 Jimenez-Quevedo, Pilar
A1 Nombela-Franco, Luis
A1 Rueda Liñares, Andrea
A1 Mahia, Patricia
A1 Marcos-Alberca, Pedro
A1 Pozo, Eduardo
A1 Gomez de Diego, Jose Juan
A1 Nuñez Gil, Ivan Javier
A1 De Agustín Loeches, José Alberto
A1 Luaces Méndez, María
A1 García Fernández, Miguel Ángel
A1 Fernández Ortiz, Antonio Ignacio
A1 Macaya Miguel, Carlos
A1 Pérez De Isla, Leopoldo
AB Background:Prosthesis-patient mismatch (PPM) after transcatheter aortic valve replacement (TAVR) remains an important issue. The aim of this study was to assess the value of a new discongruence index, to predict PPM after TAVR.Methods and Results: A total of 185 patients with severe aortic stenosis who underwent TAVR with the Edwards Sapien prosthesis or CoreValve Revalving system were included (Edwards valve, n=119; Core Valve Revalving system, n=66). Discongruence index was calculated pre-procedurally as the ratio of selected transcatheter valve size (mm) to body surface area (cm2). PPM was defined as effective orifice area (EOA) ≤0.85 cm2/m2 on transthoracic echocardiography before hospital discharge. Mean age was 82±5 years and 72 patients (38.9%) were men. The overall incidence of post-TAVR PPM was 35.1% (n=65). Discongruence index correlated with post-TAVR indexed EOA (y=0.18+0.057x; P<0.001). On multivariate logistic regression analysis, discongruence index was the only independent predictor of post-TAVR PPM (OR, 0.15; 95% CI: 0.03–0.66; P=0.012), and the area under the receiver operating characteristic curve was 0.62 (95% CI: 0.54–0.70, P=0.003), with an optimal cut-off point of 15.02 (sensitivity, 86.2%; specificity, 72.5%; positive predictive value, 74.3%; negative predictive value, 83.4%).Conclusions:The new discongruence index may be useful tool to predict PPM after TAVR.
PB J-Stage
YR 2018
FD 2018-08-23
LK https://hdl.handle.net/20.500.14352/131124
UL https://hdl.handle.net/20.500.14352/131124
LA eng
NO de Agustin JA, Islas F, Jimenez-Quevedo P, Nombela-Franco L, Rueda Liñares A, Mahia P, Marcos-Alberca P, Pozo E, Gomez de Diego JJ, Luaces M, Nuñez-Gil IJ, Garcia-Fernandez MÁ, Fernandez-Ortiz A, Macaya C, Perez de Isla L. Discongruence Index　- Simple Indicator to Predict Prosthesis-Patient Mismatch After Transcatheter Aortic Valve Replacement. Circ J. 2018 Oct 25;82(11):2880-2886. doi: 10.1253/circj.CJ-18-0298. Epub 2018 Aug 23. PMID: 30135324.
DS Docta Complutense
RD 19 mar 2026