RT Book, Section
T1 Healthy and pathological neurocognitive aging: spectral and functional connectivity analyses using magnetoencephalography
A1 Susi, Gianluca
A1 De Frutos Lucas, Jaisalmer
A1 Niso, Guiomar
A1 Ye Chen, Su Miao
A1 Antón Toro, Luis Fernando
A1 Chino Vilca, Brenda Nadia
A1 Maestu Unturbe, Fernando
AB Oscillatory activity present in brain signals reflects the underlying time-varying electrical discharges within and between ensembles of neurons. Among the variety of non-invasive techniques available for measuring of the brain’s oscillatory activity, magnetoencephalography (MEG) presents a remarkable combination of spatial and temporal resolution, and can be used in resting-state or task-based studies, depending on the goals of the experiment.Two important kinds of analysis can be carried out with the MEG signal: spectral a. and functional connectivity (FC) a. While the former provides information on the distribution of the frequency content within distinct brain areas, FC tells us about the dependence or interaction between the signals stemming from two (or among many) different brain areas.The large frequency range combined with the good resolution offered by MEG makes MEG-based spectral and FC analyses able to highlight distinct patterns of neurophysiological alterations during the aging process in both healthy and pathological conditions. Since disruption in spectral content and functional interactions between brain areas could be accounted for by early neuropathological changes, MEG could represent a useful tool to unveil neurobiological mechanisms related to the cognitive decline observed during aging, particularly suitable for the detection of functional alterations, and then for the discovery of potential biomarkers in case of pathology.The aging process is characterized by alterations in the spectral content across the brain. At the network level, FC studies reveal that older adults experience a series of changes that make them more vulnerable to cognitive interferences.While special attention has been dedicated to the study of pathological conditions (in particular, mild cognitive impairment and Alzheimer’s disease), the lack of studies addressing the features of FC in healthy aging is noteworthy. This area of research calls for future attention because it is able to set the baseline from which to draw comparisons with different pathological conditions
PB Oxford University Press
SN 9780190236557
YR 2019
FD 2019-03-26
LK https://hdl.handle.net/20.500.14352/117097
UL https://hdl.handle.net/20.500.14352/117097
LA eng
NO Susi, G., de Frutos-Lucas, J., Niso, G., Ye-Chen, S., Toro, L., Chino Vilca, B., & Maestú, F.  (2019, March 26). Healthy and Pathological Neurocognitive Aging: Spectral and Functional Connectivity Analyses Using Magnetoencephalography. Oxford Research Encyclopedia of Psychology. Retrieved 29 Jan. 2025, from https://oxfordre.com/psychology/view/10.1093/acrefore/9780190236557.001.0001/acrefore-9780190236557-e-387.
NO FPU 14/03860
NO Ministerio de Economia y Competitividad (España)
NO Ministerio de Educación Cultura y Deportes (España)
DS Docta Complutense
RD 9 abr 2025