RT Journal Article
T1 Effect of Roux-en-Y gastric surgery on ciprofloxacin pharmacokinetics: an obvious effect?
A1 Rivas Paterna, Ana Belén
A1 Lopez Picado, Amanda
A1 Salas Bruton, Maria del Rosario
A1 Terleira Fernández, Ana Isabel
A1 Sánchez Pernaute, Andrés
A1 Torres García, Antonio José
A1 Moreno Lopera, Carmen
A1 Chicharro, Luis Miguel
A1 Bandrés Moya, Fernando
A1 Rubio Herrera, Miguel Ángel
A1 Portolés Pérez, Antonio
A1 Vargas Castrillón, Emilio
AB PurposeTo evaluate pharmacokinetic parameters of ciprofloxacin in patients undergoing Roux-en-Y gastric surgery (RYGS).MethodsControlled, single-dose, open-label study in patients undergoing RYGS. Healthy overweight/obese patients 18–60 years old were included. The assessment was performed once in control patients and three times in case patients (before surgery and 1 and 6 months after surgery). In each visit, the subjects received a single oral dose of ciprofloxacin 500 mg. Venous blood samples were obtained at baseline and 0.5, 1, 1.25, 1.5, 1.75, 2, 2.5, 3, 4, 8 and 14 h after ciprofloxacin intake. Pre- and post-surgery variables were compared using paired ANOVA or the Wilcoxon tests and control vs cases using ANOVA or Mann Whitney. Given the post-surgery change in body weight, the parameters were corrected by dose (mg)/body weight (kg). The analysis was performed using SPSS.ResultsCiprofloxacin Cmax was significantly reduced 1 month after surgery (1840.9 ± 485.2 vs 1589.6 ± 321.8 ng/ml; p = 0.032) but not 6 months after. Cmax on the sixth month was lower than Cmax in control group (2160.4 ± 408.6 vs 1589.6 ± 321.8 ng/ml; p < 0.001). After correcting by the dose (mg)/patient’s body weight, both Cmax and AUClast showed significant decrease 1 and 6 months after surgery: Cmax, 289.1 ± 65.3 and 263.5 ± 52.1 (ng/ml)/(dose (mg)/weight (kg)) respectively vs 429.3 ± 127.6 (ng/ml)/(dose (mg)/weight (kg)) at baseline; AUC, 1340.6 ± 243.0 and 1299.2 ± 415.4 (h × ng/ml)/(dose (mg)/weight (kg)) respectively vs 1896.7 ± 396.8 (h × ng/ml)/(dose (mg)/weight (kg)) at baseline. Cmax 1 month post-surgery showed lower values than the control group (375.4 ± 77.4 vs 263.5 ± 52.1 ng/ml; p < 0.001).ConclusionCiprofloxacin absorption is impaired 1 month and 6 months after RYGS. The effect on Cmax and AUClast faded on the sixth month due to weight loss. It is no necessary to modify the doses of ciprofloxacin in these patients.
PB Springer Nature
SN 0031-6970
YR 2019
FD 2019-01-16
LK https://hdl.handle.net/20.500.14352/117478
UL https://hdl.handle.net/20.500.14352/117478
LA eng
NO Rivas, A.B., Lopez-Picado, A., Salas-Butrón, M.d. et al. Effect of Roux-en-Y gastric surgery on ciprofloxacin pharmacokinetics: an obvious effect?. Eur J Clin Pharmacol 75, 647–654 (2019). https://doi.org/10.1007/s00228-018-02623-8
NO ISCIII
DS Docta Complutense
RD 7 abr 2025