RT Journal Article T1 The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome A1 Marcos Delgado, Alba A1 Fernández Villa, Tania A1 Martínez González, Miguel Ángel A1 Salas Salvadó, Jordi A1 Corella, Dolores A1 Castañer, Olga A1 Martínez, J. Alfredo A1 Alonso Gómez, Ángel M. A1 Wärnberg, Julia A1 Vioque, Jesús A1 Romaguera, Dora A1 López Miranda, José A1 Estruch, Ramon A1 Tinahones, Francisco J A1 Lapetra, José A1 Serra Majem, J. LLuís A1 García-Molina, Laura A1 Tur, Josep A. A1 De Paz, José Antonio A1 Pintó, Xavier A1 Delgado Rodríguez, Miguel A1 Matía Martín, María Del Pilar A1 Vidal, Josep A1 Vázquez, Clotilde A1 Daimiel, Lidia A1 Ros, Emilio A1 Babio, Nancy A1 Gimenez Alba, Ignacio M. A1 Toledo, Estefanía A1 Zomeño, María Dolores A1 Zulet, María Ángeles A1 Vaquero Luna, Jessica A1 Pérez López, Jessica A1 Pastor Morel, Ana A1 Galmés Panadés, Aina María A1 García Rios, Antonio A1 Casas, Rosa A1 Bernal López, María Rosa A1 Santos Lozano, José Manuel A1 Becerra Tomás, Nerea A1 Ortega Azorín, Carolina A1 Vázquez Ruiz, Zenaida A1 Pérez Vega, Karla Alejandra A1 Abete, Itziar A1 Sorto Sánchez, Carolina A1 Palau Galindo, Antoni A1 Galilea Zabalza, Iñigo A1 Muñoz Martínez, Júlia A1 Martín, Vicente AB The main objective of this study was to examine the relationship between the level of physical activity (PA) and the degree of obesity with health-related quality of life (HRQoL) in individuals with metabolic syndrome (MetS) who participated in the Predimed-Plus study. A total of 6875 subjects between 55 and 75 years of age with MetS were selected and randomized in 23 Spanish centers. Subjects were classified according to categories of body mass index (BMI). PA was measured with the validated Registre Gironí del Cor (REGICOR) questionnaire and subjects were classified according to their PA level (light, moderate, vigorous) and the HRQoL was measured with the validated short-form 36 (SF-36) questionnaire. By using the ANOVA model, we found a positive and statistically significant association between the level of PA and the HRQoL (aggregated physical and mental dimensions p < 0.001), but a negative association with higher BMI in aggregated physical dimensions p < 0.001. Furthermore, women obtained lower scores compared with men, more five points in all fields of SF-36. Therefore, it is essential to promote PA and body weight control from primary care consultations to improve HRQoL, paying special attention to the differences that sex incurs. PB MDPI SN 1660-4601 YR 2020 FD 2020-05-25 LK https://hdl.handle.net/20.500.14352/8242 UL https://hdl.handle.net/20.500.14352/8242 LA eng NO European Commission NO Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional NO Junta de Andalucía NO Generalitat Valenciana DS Docta Complutense RD 27 dic 2025