RT Journal Article
T1 Oxidative Stress Score as an Indicator of Pathophysiological Mechanisms Underlying Cardiovascular Disease in Kidney Transplant Recipients
A1 Valera Arévalo, Gemma
A1 Caro, Paula Jara
A1 Rodríguez San Pedro, María del Mar
A1 Yuste, Claudia
A1 Ortiz Díaz, María Gabriela
A1 Ramírez, Rafael
A1 Alique, Matilde
A1 Guerra Pérez, Natalia
A1 Carracedo Añón, Julia María
A1 Morales Ruiz, Enrique
AB Chronic kidney disease is closely associated with an increased risk of cardiovascular disease. Although kidney transplantation represents the treatment of choice for patients with end-stage chronic kidney disease, it is also linked to significant cardiovascular risk. This study aimed to evaluate the relationship between cardiovascular pathology and oxidative status in kidney transplant recipients, while also assessing the influence of disease etiology and humoral immune response on oxidative imbalance. A cross-sectional analysis was conducted in individuals with advanced chronic kidney disease (n = 36) and kidney transplant recipients (n = 40). A total of 18 healthy subjects were included. The enzymatic activities of xanthine oxidase, superoxide dismutase, and glutathione peroxidase, and levels of lipid peroxidation products, oxidized glutathione, and reduced glutathione were measured using spectrophotometry in plasma and mononuclear and polymorphonuclear leukocytes isolated using Ficoll density gradients. Individual oxidative status was evaluated using OXYSCORE. Kidney transplantation was associated with a higher incidence of cardiovascular disease (p < 0.01) and increased levels of both prooxidant (p < 0.01) and antioxidant parameters (p < 0.01). Elevated OXYSCORE values were observed particularly in patients with nephroangiosclerosis, diabetic kidney disease, polycystic kidney disease (p < 0.05), and cardiovascular comorbidities (p < 0.001). Additionally, the presence of anti-graft antibodies correlated with higher oxidative scores. These findings suggest that OXYSCORE may serve as a potential indicator of cardiovascular damage in kidney transplant recipients.
PB MDPI
SN 2673-9801
YR 2025
FD 2025-10-16
LK https://hdl.handle.net/20.500.14352/134012
UL https://hdl.handle.net/20.500.14352/134012
LA eng
NO Gemma, V.-A., Caro, P. J., Rodríguez-San Pedro, M. d. M., Yuste, C., Ortiz-Diaz, M. G., Ramírez, R., Alique, M., Guerra-Pérez, N., Carracedo, J., & Morales, E. (2025). Oxidative Stress Score as an Indicator of Pathophysiological Mechanisms Underlying Cardiovascular Disease in Kidney Transplant Recipients. Oxygen, 5(4), 20. https://doi.org/10.3390/OXYGEN5040020
NO This research was funded by the Instituto de Salud Carlos III through projects “PI17/01029”, “PI19/00240”, “PI20/01321”, and project PI23/01109, funded by the Carlos III Health Institute (ISCIII) and co-funded by the European Union. This research was also funded by grants from the Instituto de Salud Carlos III (ISCIII) and cofounded by Fondos Europeos de Desarrollo Regional (FEDER): “EPU-INV-UAH/2022/001” from Universidad de Alcala (“Ayuda de la Linea de Actuacion Excelencia para el Profesorado Universitario de la UAH”) to M.A. RICORS 2040. G.V.-A. was supported by imas12 contract “I+12-AY2OO414-1”, and M.d.M.R.-S.P. received FPU23/00347.
NO Instituto de Salud Carlos III
NO European Commission
NO Universidad de Alcalá de Henares
DS Docta Complutense
RD 21 mar 2026