RT Journal Article
T1 Mortality after pulmonary embolism in patients with diabetes. Findings from the RIETE registry
A1 Miguel Díez, Javier De
A1 López De Andrés, Ana Isabel
A1 Jiménez-Trujillo, Isabel
A1 Hernández-Barrera, Valentín
A1 Jiménez García, Rodrigo
A1 Lorenzo, Alicia
A1 Pedrajas Navas, José María
A1 Visonà, Adriana
A1 López-Miguel, Patricia
A1 Monreal, Manuel
AB Background: Among patients presenting with pulmonary embolism (PE), those with diabetes are at increased risk to die than those without diabetes. The reasons have not been identified. We used the RIETE (Registro Informatizado Enfermedad Trombo Embólica) database to compare the mortality rate and the causes of death during anticoagulation in patients with PE according to the presence or absence of diabetes.Methods: A matched retrospective cohort study from consecutively enrolled patients in RIETE, from 179 hospitals in 24 countries. For each patient with diabetes we selected two patients with no diabetes matched by age, sex and year of diagnosis of the PE.Results: As of September 2017, there were 2010 PE patients with diabetes and two age-and-gender matched controls. Mean age was 74 ± 11 years, 46% were men. Patients with diabetes were more likely to have co-morbidities, to be using antiplatelets and to have more severe PE. During anticoagulation (median, 219 days), patients with diabetes had a higher mortality (hazard ratio [HR]: 1.45; 95% confidence intervals [CI]: 1.25-1.67) and a higher rate of arterial ischemic events (HR: 2.89; 95%CI: 1.71-4.94) than those without diabetes. On multivariable analysis, diabetes was not associated with an increased risk for death (HR: 1.26; 95%CI: 0.97-1.63). We also failed to find differences according to the use of antiplatelet drugs concomitantly.Conclusions: In our cohort of patients with PE, diabetes was not an independent predictor for death. The influence of arterial events or antiplatelet drugs (if any) was low.
PB Elsevier
SN 0953-6205
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/98322
UL https://hdl.handle.net/20.500.14352/98322
LA eng
NO de Miguel-Díez J, López-de-Andrés A, Jiménez-Trujillo I, Hernández-Barrera V, Jiménez-García R, Lorenzo A, Pedrajas JM, Visonà A, López-Miguel P, Monreal M; RIETE Investigators. Mortality after pulmonary embolism in patients with diabetes. Findings from the RIETE registry. Eur J Intern Med. 2019 Jan;59:46-52. doi: https//doi.org/10.1016/j.ejim.2018.08.001. Epub 2018 Aug 9. PMID: 30100215.
DS Docta Complutense
RD 15 dic 2025