RT Journal Article
T1 Serum biomarkers in uncontrolled no heart-beating donors may identify kidneys that will never work after transplantation
A1 López Farre, Antonio José
A1 Santos Sancho, Juana María
A1 Modrego, Javier
A1 Zamorano León, José Javier
A1 Martín, Leyre
A1 Sánchez Fructuoso, Ana Isabel
A1 Rodríguez Sierra, Pablo
A1 Herrero Calvo, José Antonio
A1 Río Gallegos, Francisco José Del
A1 Barrientos Alberto, 
A1 Barrientos Guzmán, Alberto
AB Background/aimsKidneys from uncontrolled non heart-beating donors achieve a good level of renal function after transplantation. However, a number of them will never function in the recipient. Our aim was to determine if serum biomarkers associated with platelet activity, inflammation and the nitric oxide system in uncontrolled non heart-beating donors may help to predict no renal function recovery after renal transplantation.MethodsSerum levels of interleukin (IL)-6, IL-10, intercellular cell adhesion molecule-1 (ICAM-1), cyclic guanosine monophosphate (cGMP), nitrite + nitrate and platelet factor-4 (PF4) were measured using enzyme-linked immunosorbent assay (ELISA) kits in 88 uncontrolled non heart-beating donors divided according to the renal functionality achieved in the recipients into functional (n = 76) and non functional (n = 12).ResultsKidneys from donors with higher IL-6 levels (>900 pg/ml) were functional after transplantation. Serum cGMP levels below 372.3 fmol/l were also associated with kidneys that recovered the renal function. However, serum levels of PF4 showed the best correlation with recovery of renal functional in the recipients since they were significantly lower in the donors whose kidneys functioned after transplantation.ConclusionsSerum PF4 levels in uncontrolled non heart-beating donors may be a good predictor for kidneys that never will reach functional recovery. Some serum cGMP, IL-6 and IL-10 levels may simply help identify kidneys that will function after transplantation.
PB Springer
SN 1724-6059
YR 2016
FD 2016-07-01
LK https://hdl.handle.net/20.500.14352/99309
UL https://hdl.handle.net/20.500.14352/99309
LA eng
NO López-Farré, A.J., Santos-Sancho, J.M., Modrego, J. et al. Serum biomarkers in uncontrolled no heart-beating donors may identify kidneys that will never work after transplantation. J Nephrol 29, 119–127 (2016). https://doi.org/10.1007/s40620-015-0203-3
NO Fondo de Investigaciones de la Seguridad Social
NO Fondo Europeo de Desarrollo Regional
DS Docta Complutense
RD 10 abr 2025