RT Journal Article
T1 Systemic administration of immunostimulatory DNA sequences mediates reversible inhibition of Th2 responses in a mouse model of asthma
A1 Broide, David H.
A1 Stachnick, Greg
A1 Castaneda, Diego
A1 Nayar, Jyothi
A1 Miller, Marina
A1 Cho, Jae Youn
A1 Roman, Mark
A1 Zubeldia Ortuño, José Manuel
A1 Hyashi, Tomoko
A1 Raz, Eyal
AB This study investigated whether immunostimulatory DNA sequences (ISS) induce a transient or sustained inhibition of Th2 responses to inhaled antigen. We sensitized mice with subcutaneous injections to develop a Th2 response to ovalbumin (ova) and then administered a dose of ISS prior to ova inhalation challenge. Mice were then rechallenged with ova byinhalation a second time at varying time points after the first ova inhalation (1 to 8 weeks later) to determine whether the ISS dose administered prior to the first ova inhalation protected against a subsequent second ova inhalation challenge. A single dose of ISS inhibited the Th2 response to the first inhalation of ova antigen, as well as 4 weeks later to the second inhalation of ova. However, ISS did not inhibit a Th2 response to the second inhalation of ova 8 weeks later. The reversible inhibition of Th2 responses at 8 weeks suggests the need for repeated ISS administration at monthly intervals.
PB Springer Nature
SN 0271-9142
YR 2001
FD 2001-05-01
LK https://hdl.handle.net/20.500.14352/95765
UL https://hdl.handle.net/20.500.14352/95765
LA eng
NO Broide DH, Stachnick G, Castaneda D, Nayar J, Miller M,  Cho JY, Roman M, Zubeldia J, Hayashi T, Raz E. Systemic administration of immunostimulatory DNA sequences mediates reversible inhibition of Th2 responses in a mouse model of asthma.  Actions Share  Page navigation      Title & authors     Erratum in     Abstract     Similar articles     Cited by     References     Publication types     MeSH terms     Substances     Related information     Grants and funding     LinkOut - more resources  J Clin Immunol  . 2001 May;21(3):175-82.
DS Docta Complutense
RD 26 dic 2025