RT Journal Article
T1 Zika Virus Pathogenesis: A Battle for Immune Evasion
A1 Estévez-Herrera, Judith
A1 Pérez-Yanes, Silvia
A1 Cabrera-Rodríguez, Romina
A1 Márquez-Arce, Daniel
A1 Trujillo-González, Rodrigo
A1 Machado, José-David
A1 Madrid González, Ricardo
A1 Valenzuela-Fernández, Agustín
AB Zika virus (ZIKV) infection and its associated congenital and other neurological disorders, particularly microcephaly and other fetal developmental abnormalities, constitute a World Health Organization (WHO) Zika Virus Research Agenda within the WHO’s R&D Blueprint for Action to Prevent Epidemics, and continue to be a Public Health Emergency of International Concern (PHEIC) today. ZIKV pathogenicity is initiated by viral infection and propagation across multiple placental and fetal tissue barriers, and is critically strengthened by subverting host immunity. ZIKV immune evasion involves viral non-structural proteins, genomic and non-coding RNA and microRNA (miRNA) to modulate interferon (IFN) signaling and production, interfering with intracellular signal pathways and autophagy, and promoting cellular environment changes together with secretion of cellular components to escape innate and adaptive immunity and further infect privileged immune organs/tissues such as the placenta and eyes. This review includes a description of recent advances in the understanding of the mechanisms underlying ZIKV immune modulation and evasion that strongly condition viral pathogenesis, which would certainly contribute to the development of anti-ZIKV strategies, drugs, and vaccines.
PB MDPI
SN 2076-393X
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/97764
UL https://hdl.handle.net/20.500.14352/97764
LA eng
NO Estévez-Herrera, J.; Pérez-Yanes, S.; Cabrera-Rodríguez, R.; Márquez-Arce, D.; Trujillo-González, R.; Machado, J.-D.; Madrid, R.; Valenzuela-Fernández, A. Zika Virus Pathogenesis: A Battle for Immune Evasion. Vaccines 2021, 9, 294. https://doi.org/10.3390/vaccines9030294
NO European Commission
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Instituto de Salud Carlos III
NO Gobierno de Canarias
NO Red Temática Cooperativa de Investigación en SIDA
DS Docta Complutense
RD 20 abr 2025