RT Journal Article T1 Visual function, ocular surface integrity and symptomatology of a new extended depth-of-focus and a conventional multifocal contact lens A1 Martínez Alberquilla, Irene A1 García Montero, María A1 Ruiz Alcocer, Javier A1 Crooke Álvarez, Almudena A1 Madrid Costa, David AB Purpose: To evaluate visual function, ocular surface integrity and dry eye symptoms with an extended depth-of-focus (EDOF) design and a conventional multifocal (MF) contact lens (CL) after 15 days of wear.Methods: A crossover single mask randomised clinical trial was conducted including 30 presbyopes who used an EDOF and a conventional MF CL (Biofinity MF) for 15 days each. Defocus curves, depth-of-focus range, contrast sensitivity (CS) under photopic and mesopic conditions (with and without glare) and subjective perception of halos and glare were evaluated. The ocular surface was evaluated through non-invasive Keratograph tear breakup time (NIKBUT), averaged tear breakup time (NIKBUT-avg), tear meniscus height (TMH), bulbar and limbal redness, and conjunctival and corneal staining. Dry eye symptoms were assessed with the OSDI questionnaire.Results: No statistically significant differences were found for defocus curves or depth-of-focus between the two CLs (both p > 0.05). Subjective perception of halos and glare was not significantly different between CLs. Statistically significant differences were observed for CS under mesopic conditions for low spatial frequencies (p = 0.008). None of the CL produced significant changes in NIKBUT, NIKBUT-avg, TMH or redness. No change in conjunctival staining was observed in 76.7 % and 73.3 % of participants for EDOF and Biofinity MF, respectively. No change in corneal staining was observed in 86.7 % and 83.3 % of participants for EDOF and Biofinity MF, respectively. No changes were observed in the symptomatology measured with OSDI questionnaire (p > 0.05).Conclusions: Both CL for presbyopia offer good visual quality, preserve the ocular surface integrity and provide the patient with similar symptomatology levels after 15 days of lens wear. PB Elsevier SN 1367-0484 YR 2020 FD 2020-11-23 LK https://hdl.handle.net/20.500.14352/7859 UL https://hdl.handle.net/20.500.14352/7859 LA eng NO Martínez Alberquilla, I., García Montero, M., Ruiz Alcocer, J. et al. «Visual Function, Ocular Surface Integrity and Symptomatology of a New Extended Depth-of-Focus and a Conventional Multifocal Contact Lens». Contact Lens and Anterior Eye, vol. 44, n.o 5, octubre de 2021, p. 101384. DOI.org (Crossref), https://doi.org/10.1016/j.clae.2020.11.004. DS Docta Complutense RD 1 oct 2024