RT Journal Article
T1 Chitosan Spray-Dried Microparticles for Controlled Delivery of Venlafaxine Hydrochloride
A1 Aranaz Corral, Inmaculada
A1 Paños, Ines
A1 Peniche, Carlos
A1 Heras Caballero, Ángeles María
A1 Acosta Contreras, Florentina Niuris
AB Venlafaxine controlled drug delivery systems using different matrixes have been tested to reduce undesirable side effects in the treatment of depression. The legal status of chitosan (Cs) in Pharmacy has dramatically improved after its acceptance as excipient in several Pharmacopeias and, therefore, there is great interest in pharmaceutical formulations based on this polymer. In this paper, chitosan microcapsules cross-linked with sodium tripolyphosphate (TPP) for oral delivery of venlafaxine were formulated using the spray drying technique. The effect of chitosan physico-chemical properties, TPP concentration and TPP/Cs ratio on drug release was evaluated. The microcapsules were characterized in terms of size, zeta potential and morphology. The physical state of the drug was determined by X-ray diffraction (XRD) and the drug release from the microcapsules was studied in simulated gastric and intestinal fluids. The release pattern fitted well to the Peppas-Koersmeyer model with n exponents indicating anomalous transport.
PB MDPI
SN 1420-3049
YR 2017
FD 2017-11-15
LK https://hdl.handle.net/20.500.14352/19243
UL https://hdl.handle.net/20.500.14352/19243
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
DS Docta Complutense
RD 17 may 2024