%0 Journal Article
%A Navarro Cuéllar, Carlos
%A Sada Urmeneta, Ángela
%A Lorenzo Marcos, Raquel
%A Antúnez Conde, Raúl
%A López López, Ana
%A Castillo Pardo de Vera, José Luis del
%A González Martín Moro, Javier
%A Cebrián Carretero, José Luis
%A Alijo Serrano, Francisco
%A Zamorano León, José Javier
%A Navarro Cuéllar, Ignacio
%T Prognostic Value of Lymph Node Density in Lingual Squamous Cell Carcinoma
%D 2023
%@ 2076-3417
%U https://hdl.handle.net/20.500.14352/107381
%X Lymph node density (LND)—the proportion of positive nodes among the total number of resected nodes—has emerged as a reliable prognostic factor in solid tumors. This study aims to assess the importance of LND in lingual squamous cell carcinoma (LSCC) and its prognostic involvement. A retrospective longitudinal study with 62 patients was performed. All patients were diagnosed with LSCC and submitted for tumor resection and neck dissection. Patients were stratified into low (<0.04) and high risk (≥0.04) based on LND. We analyzed the impact of LND on overall survival (OS) and disease-free survival (DFS), as well as the relationship between LND and the pathological staging, the involvement of positive margins, depth of invasion (DOI) and perineural infiltration. This study provides a substantial relationship between lymph node density (LND), overall survival (OS) and disease-free survival (DFS) in lingual squamous cell carcinoma (LSCC). A statistically significant distribution was found between LND, perineural infiltration and pathological staging, whereas no association was found with the rest of the prognostic variables analyzed.
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