RT Journal Article
T1 Prognostic Value of Lymph Node Density in Lingual Squamous Cell Carcinoma
A1 Navarro Cuéllar, Carlos
A1 Sada Urmeneta, Ángela
A1 Lorenzo Marcos, Raquel
A1 Antúnez Conde, Raúl
A1 López López, Ana
A1 Castillo Pardo de Vera, José Luis del
A1 González Martín Moro, Javier
A1 Cebrián Carretero, José Luis
A1 Alijo Serrano, Francisco
A1 Zamorano León, José Javier
A1 Navarro Cuéllar, Ignacio
AB Lymph node density (LND)—the proportion of positive nodes among the total number of resected nodes—has emerged as a reliable prognostic factor in solid tumors. This study aims to assess the importance of LND in lingual squamous cell carcinoma (LSCC) and its prognostic involvement. A retrospective longitudinal study with 62 patients was performed. All patients were diagnosed with LSCC and submitted for tumor resection and neck dissection. Patients were stratified into low (<0.04) and high risk (≥0.04) based on LND. We analyzed the impact of LND on overall survival (OS) and disease-free survival (DFS), as well as the relationship between LND and the pathological staging, the involvement of positive margins, depth of invasion (DOI) and perineural infiltration. This study provides a substantial relationship between lymph node density (LND), overall survival (OS) and disease-free survival (DFS) in lingual squamous cell carcinoma (LSCC). A statistically significant distribution was found between LND, perineural infiltration and pathological staging, whereas no association was found with the rest of the prognostic variables analyzed.
PB MDPI
SN 2076-3417
YR 2023
FD 2023-05-01
LK https://hdl.handle.net/20.500.14352/107381
UL https://hdl.handle.net/20.500.14352/107381
LA eng
NO Navarro Cuéllar, C.; Sada Urmeneta, Á.; Lorenzo Marcos, R.; Antúnez-Conde, R.; López López, A.; del Castillo Pardo de Vera, J.L.; González Martín-Moro, J.; Cebrián Carretero, J.L.; Alijo Serrano, F.; Dell’Aversana Orabona, G.; et al. Prognostic Value of Lymph Node Density in Lingual Squamous Cell Carcinoma. Appl. Sci. 2023, 13, 5611. https://doi.org/10.3390/ app13095611
DS Docta Complutense
RD 20 may 2025