RT Journal Article
T1 Chronic unpredictable stress and long-term ovariectomy affect arginine-vasopressin expression in the paraventricular nucleus of adult female mice
A1 Grassi, Daniela
A1 Lagunas García, Luisa Natalia
A1 Calmarza-Font, Isabel
A1 Diz-Chaves, Yolanda
A1 Garcia Segura, Luis
A1 Panzica, GianCarlo
AB Arginine-Vasopressin (AVP) may regulate the hypothalamic-pituitary-adrenal axis (HPA) and its effects on depressive responses. In a recent study, we demonstrated that Chronic Unpredictable Stress (CUS) depressive effects are enhanced by long-term ovariectomy (a model of post-menopause). In the present study, we investigated the effects of long-term ovariectomy and CUS on AVP expression in different subdivision of the paraventricular nucleus (PVN) of female mice. Both long-term ovariectomy and CUS affect AVP immunoreactivity in some of the PVN subnuclei of adult female mice. In particular, significant changes on AVP immunoreactivity were observed in magnocellular subdivisions, the paraventricular lateral magnocellular (PaLM) and the paraventricular medial magnocellular (PaMM), the 2 subnuclei projecting to the neurohypophysis for the hormonal regulation of body homeostasis. AVP immunoreactivity was decreased in the PaLM by both the long-term deprivation of ovarian hormones and the CUS. In contrast, AVP immunoreactivity was increased in the PaMM by CUS, whereas it was decreased by ovariectomy. Therefore, present results suggest morphological and functional differences among the PVN's subnuclei and complex interactions among CUS, gonadal hormones and AVP immunoreactivity.
PB Elsevier
SN 0006-8993
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/95214
UL https://hdl.handle.net/20.500.14352/95214
LA eng
NO Grassi, D., et al. «Chronic Unpredictable Stress and Long-Term Ovariectomy Affect Arginine-Vasopressin Expression in the Paraventricular Nucleus of Adult Female Mice». Brain Research, vol. 1588, noviembre de 2014, pp. 55-62. https://doi.org/10.1016/j.brainres.2014.09.006.
NO Fondazione Cavalieri Ottolenghi
NO Fondazione San Paolo
NO Ministerio de Ciencia e Innovación (España)
NO University of Torino
DS Docta Complutense
RD 9 abr 2025