RT Journal Article
T1 Incidence of acquired immunodeficiency syndrome-associated opportunistic diseases and the effect of treatment on a cohort of 1115 patients infected with human immunodeficiency virus, 1989-1997
A1 San Andrés, Francisco Javier
A1 Rubio García, Rafael
A1 Castilla, Jesús
A1 Pulido Ortega, Federico
A1 Palao, Guillermo
A1 Pedro, Inmaculada de
A1 Costa Pérez-Herrero, José Ramón
A1 Palacio Pérez-Medel, Ángel Del
AB Temporal trends in the incidence of opportunistic diseases (ODs) related to acquired immunodeficiency syndrome (AIDS) were studied during 1989-1997 in 1115 outpatients infected with human immunodeficiency virus (331 of whom had AIDS) in a hospital in Madrid, Spain. We analyzed the effect of adherence to antiretroviral therapy and Pneumocystis carinii pneumonia (PCP) prophylaxis on the incidence of OD. Diseases that showed a significant decreasing trend were esophageal candidiasis, pulmonary and extrapulmonary tuberculosis, and cerebral toxoplasmosis. Patients who adhered to antiretroviral therapy had a smaller risk of OD. Patients who adhered to PCP prophylaxis had a reduced risk of cerebral toxoplasmosis and PCP. A reduction in the incidence of AIDS-related ODs was observed, mainly in patients who underwent prophylaxis. Adherence to antiretroviral treatment and PCP prophylaxis was associated with a reduction in the risk of disease.
PB Oxford Academic
YR 2003
FD 2003-05-01
LK https://hdl.handle.net/20.500.14352/107329
UL https://hdl.handle.net/20.500.14352/107329
LA eng
NO San-Andrés FJ, Rubio R, Castilla J, Pulido F, Palao G, de Pedro I, Costa JR, del Palacio A. Incidence of acquired immunodeficiency syndrome-associated opportunistic diseases and the effect of treatment on a cohort of 1115 patients infected with human immunodeficiency virus, 1989-1997. Clin Infect Dis. 2003 May 1;36(9):1177-85.
DS Docta Complutense
RD 10 abr 2025