RT Journal Article T1 The Impact of Depression Symptoms in Patients with Parkinson’s Disease: A Novel Case-Control Investigation A1 Jiménez Cebrián, Ana A1 Becerro De Bengoa Vallejo, Ricardo A1 Losa Iglesias, Marta Elena A1 López López, Daniel A1 Calvo Lobo, César A1 Palomo López, Patricia A1 Romero Morales, Carlos A1 Navarro Flores, Emmanuel AB Parkinson’s disease is a common neurodegenerative disease and it is known to cause motor disturbances associated with musculoskeletal problems of the locomotor apparatus, and non-motor symptoms, that are believed to have a harmful effect on health, social functioning and mobility. The aim of this study was to evaluate depression in patients with Parkinson’s Disease (PD) compared to subjects who do not have it. The sample consisted of 124 participants (mean age 69.18 ± 9.12). Patients with PD were recruited from a center of excellence for Parkinson’s disease (cases n = 62) and healthy subjects without PD from their relatives and caregivers (control n = 62). The Spanish version of Beck’s Depression Inventory (BDI) scores and categories were collected. A clear statistically significant difference (p < 0.05) was evident in the BDI scores between both groups. Parkinson’s patients presented worse results on the BDI = 15.48 ± 7.24 points compared to healthy subjects with BDI = 7.03 ± 6.99 points. Regarding BDI categories, there were statistically significant differences (p < 0.001) for the greater BDI categories in the Parkinson’s group compared with healthy subjects. The depression represents an important potential risk for increased symptoms and negative impact among patients with PD compared with healthy subjects. PB MPDI SN 1660-4601 YR 2021 FD 2021-02-25 LK https://hdl.handle.net/20.500.14352/6923 UL https://hdl.handle.net/20.500.14352/6923 LA eng NO Generalitat Valenciana DS Docta Complutense RD 6 abr 2025