RT Journal Article
T1 Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi
A1 Muñoz, Juan José
A1 García Ceca Hernández, Javier
A1 Montero Herradón, Sara
A1 Sánchez del Collado, Beatriz
A1 Alfaro Sánchez, David
A1 Zapata González, Agustín
AB For a long time, the effects of distinct Eph tyrosine kinase receptors and their ligands, ephrins on the structure, immunophenotype, and development of thymus and their main cell components, thymocytes (T) and thymic epithelial cells (TECs), have been studied. In recent years, the thymic phenotype of mutant mice deficient in several Ephs and ephrins B has been determined. Remarkably, thymic stroma in these animals exhibits important defects that appear early in ontogeny but little alterations in the proportions of distinct lymphoid cell populations. In the present manuscript, we summarize and extend these results discussing possible mechanisms governing phenotypical and functional thymocyte maturation in an absence of the critical T–TEC interactions, concluding that some signaling mediated by key molecules, such as MHCII, CD80, β5t, Aire, etc. could be sufficient to enable a proper maturation of thymocytes, independently of morphological alterations affecting thymic epithelium
PB Frontiers Media
SN ESSN: 1664-2392
YR 2018
FD 2018-04-03
LK https://hdl.handle.net/20.500.14352/12126
UL https://hdl.handle.net/20.500.14352/12126
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 10 abr 2025