RT Journal Article
T1 Probiotic effects of orally administered Lactobacillus reuteri-containing tablets on the subgingival and salivary microbiota in patients with gingivitis. A randomized clinical trial
A1 Iniesta Albentosa, Margarita Isabel
A1 Herrera González, David
A1 Montero Solís, Eduardo
A1 Zurbriggen, Milena
A1 Matos, Ana
A1 Marín Cuenda, María José
A1 Sánchez Beltrán, María Del Carmen
A1 Llama Palacios, María Arantxazu
A1 Sanz Alonso, Mariano
AB Objective: To investigate the effects of an orally administered probiotic on the oral microbiota.Methods: A placebo-controlled, parallel study was conducted in 40 gingivitis subjects during 8 weeks. Treatment consisted on the administration of a daily tablet, either containing Lactobacillus reuteri or placebo. Unstimulated saliva and subgingival samples were collected and analysed by culture and PCR. Clinical and microbiological outcome variables were compared between and within groups.Results: There were no significant changes between and within the groups in the clinical variables. In saliva, total anaerobic counts after 4 weeks (p = 0.021) and counts of Prevotella intermedia after 8 weeks (p = 0.030), showed reductions in the test group. In subgingival samples, significant reductions in the changes baseline to 4 weeks were observed for P. gingivalis counts (p = 0.008). With PCR, L. reuteri ATCC-PTA-5289 was more frequently detected than L. reuteri DSM-17938.Conclusions: The effect of L. reuteri administered in tablets resulted in a reduction in the number of selected periodontal pathogens in the subgingival microbiota, without an associated clinical impact.
PB Willey
SN 0303-6979
YR 2012
FD 2012
LK https://hdl.handle.net/20.500.14352/94481
UL https://hdl.handle.net/20.500.14352/94481
LA eng
NO Iniesta M, Herrera D, Montero E, Zurbriggen M, Matos AR, Marín MJ, Sánchez-Beltrán MC, Llama-Palacio A, Sanz M. Probiotic effects of orally administered Lactobacillus reuteri-containing tablets on the subgingival and salivary microbiota in patients with gingivitis. A randomized clinical trial. J Clin Periodontol. 2012 Aug;39(8):736-44.
DS Docta Complutense
RD 7 abr 2025