RT Journal Article
T1 Citrus essential oils inhalation by mice: Behavioral testing, GCMS plasma analysis, corticosterone, and melatonin levels evaluation
A1 Nunes Wolffenbüttel, Adriana
A1 Zamboni, Amanda
A1 Becker, Gabriela
A1 Kerpel Dos Santos, Maíra
A1 Tassi Borille, Bruna
A1 Cássia Mariotti, Kristiane de
A1 Fagundes, Ana Claudia
A1 Lucas de Oliveira Salomón, Janaína
A1 Rodrigues Coelho, Vanessa
A1 Moura Linck, Viviane de
A1 Dallegrave, Eliane
A1 Cano, Pilar
A1 Esquifino, Ana Isabel
A1 Pereira Limberger, Renata
A1 Virto Ruiz, Leire
A1 Cano Barquilla, María Pilar
A1 Esquifino Parras, Ana Isabel
AB The use of orange essential oils (EOs) as a complementary treatment is very common in Brazilian popular culture. The levels of melatonin (MEL) and corticosterone (CORT) hormones were investigated simultaneously, by the Luminex™ immunoassay system in mice plasma, after Citrus aurantium and Citrus sinensis EOs inhalation for 30 min. The plasma was analyzed by headspace through gas chromatography coupled to mass spectrometry for investigation of the EO components. Mice were submitted to behavioral testing to research anxiolytic-like, sedative, and antidepressant-like effects. The inhalation of atmosphere obtained from vaporization of 10% solution of this Citrus EO separately did not affect MEL or CORT plasma levels; that is, the MEL and CORT levels did not present variation in function of the EO in the schedule used. On the other hand, the imipramine positive control used altered the level of MEL as expected. The EO constituents were detected in plasma at different ratios that is present in inhaled EO. Behavioral tests showed that the inhalation of 10% C. sinensis EO presents an anxiolytic-like and sedative effect. Thus, C. sinensis EO can be a valuable tool for treatment of the anxiety disturbs, apparently without interference with MEL and CORT physiological levels.
PB Wiley on line Library
SN 0951-418X
YR 2017
FD 2017-11-23
LK https://hdl.handle.net/20.500.14352/94170
UL https://hdl.handle.net/20.500.14352/94170
LA eng
NO Wolffenbüttel AN, Zamboni A, Becker G, Dos Santos MK, Borille BT, de Cássia Mariotti K, Fagundes AC, de Oliveira Salomón JL, Coelho VR, Ruiz LV, de Moura Linck V, Dallegrave E, Cano P, Esquifino AI, Leal MB, Limberger RP. Citrus essential oils inhalation by mice: Behavioral testing, GCMS plasma analysis, corticosterone, and melatonin levels evaluation. Phytother Res. 2018 Jan;32(1):160-169
NO Issue Online: 11 January 2018Version of Record online: 23 November 2017Manuscript accepted: 03 October 2017Manuscript revised: 30 September 2017Manuscript received: 02 August 2016
NO Consejo Nacional de Desarrollo Científico y Tecnológico (CNPq) (Brasil)
NO Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) (Brasil)
DS Docta Complutense
RD 22 abr 2025