RT Journal Article
T1 Study of red wine neuroprotection on astrocytes
A1 Gómez-Serranillos Cuadrado, María Pilar
A1 Martín, Sara
A1 Ortega Hernández-Agero, María Teresa
A1 Palomino Ruiz-Poveda, Olga María
A1 Prodanov, Marín
A1 Vacas, Visitación
A1 Hernández, Teresa
A1 Estrella, Isabel
A1 Carretero Accame, María Emilia
AB Phenolic composition of wine depends not only on the grape variety from which it is made, but on some external factors such as winemaking technology. Red wine possesses the most antioxidant effect because of its high polyphenolic content. The aim of this work is to study for the first time, the neuroprotective activity of four monovarietal Spanish red wines (Merlot (ME), Tempranillo (T), Garnacha (G) and Cabernet-Sauvignon (CS)) through its antioxidant ability, and to relate this neuroprotection to its polyphenolic composition, if possible. The wine effect on neuroprotection was studied through its effect as free radical scavenger against FeSO4, H2O2 and FeSO4 + H2O2. Effect on cell survival was determined by 3(4,5-dimethyltiazol-2-il)-2,5-diphenyltetrazolium reduction assay (MTT) and lactate dehydrogenase (LDH) release assay on astrocytes cultures. Results showed that most of the studied wine varieties induced neuroprotection through their antioxidant ability in astrocytes, Merlot being the most active; this variety is especially rich in phenolic compounds, mainly catechins and oligomeric proanthocyanidins. Our results show that red wine exerts a protection against oxidative stress generated by different toxic agents and that the observed neuroprotective activity is related to their polyphenolic content.
PB Springer
YR 2009
FD 2009
LK https://hdl.handle.net/20.500.14352/97694
UL https://hdl.handle.net/20.500.14352/97694
LA eng
NO Gómez-Serranillos MP, Martín S, Ortega T, Palomino OM, Prodanov M, Vacas V, Hernández T, Estrella I, Carretero ME. Study of red wine neuroprotection on astrocytes. Plant Foods Hum Nutr. 2009 Dec;64(4):238-43.
DS Docta Complutense
RD 10 abr 2025