RT Journal Article
T1 Maternal Supplementation of Vitamin E or Its Combination with Hydroxytyrosol Increases the Gut Health and Short Chain Fatty Acids of Piglets at Weaning
A1 Laviano, Hernan D.
A1 Gómez, Gerardo
A1 Nuñez, Yolanda
A1 García-Casco, Juan M.
A1 Muñoz, María
A1 González-Bulnes, Antonio
A1 Óvilo, Cristina
A1 Escudero Portugués, Rosa María
A1 De las Heras Molina, Ana
A1 López Bote, Clemente José
A1 Rey Muñoz, Ana Isabel
AB An adequate intestinal environment before weaning may contribute to diarrhea predisposition and piglet development. This study evaluates how the dietary supplementation of vitamin E (VE) (100 mg/kg), hydroxytyrosol (HXT) (1.5 mg/kg) or the combined administration (VE + HXT) given to Iberian sows from gestation affects the piglet’s faecal characteristics, short chain fatty acids (SCFAs), fatty acid profile or intestinal morphology as indicators of gut health; and quantify the contribution of the oxidative status and colostrum/milk composition to the piglet’s SCFAs content and intestinal health. Dietary VE increased isobutyric acid (iC4), butyric acid (C4), isovaleric acid (iC5), and ∑SCFAs, whereas HXT increased iC4 and tended to decrease ∑SCFAs of faeces. Piglets from HXT-supplemented sows also tended to have higher faecal C20:4n-6/C20:2 ratio C22:6 proportion and showed lower occludin gene expression in the duodenum. The combination of both antioxidants had a positive effect on iC4 and iC5 levels. Correlation analyses and regression equations indicate that faecal SCFAs were related to oxidative status (mainly plasma VE) and colostrum and milk composition (mainly C20:2, C20:3, C20:4 n-6). This study would confirm the superiority of VE over HXT supplementation to improve intestinal homeostasis, gut health, and, consequently piglet growth.
PB MDPI
SN 2076-3921
YR 2023
FD 2023-09-13
LK https://hdl.handle.net/20.500.14352/101735
UL https://hdl.handle.net/20.500.14352/101735
LA eng
NO Laviano, H.D.; Gómez, G.; Escudero, R.; Nuñez, Y.; García-Casco, J.M.; Muñoz, M.; Heras-Molina, A.; López-Bote, C.; González-Bulnes, A.; Óvilo, C.; et al. Maternal Supplementation of Vitamin E or Its Combination with Hydroxytyrosol Increases the Gut Health and Short Chain Fatty Acids of Piglets at Weaning. Antioxidants 2023, 12, 1761. https://doi.org/ 10.3390/antiox12091761
NO MINECO
NO Agencia estatal de investigación
NO IRAF-Sanchez Romero Carvajal
NO European Regional Development Fund
DS Docta Complutense
RD 10 abr 2025