RT Journal Article
T1 Metabolic effects of second-generation antipsychotics in bipolar youth: comparison with other psychotic and non-psychotic diagnoses
A1 Moreno Ruiz, María del Carmen
A1 Merchán Naranjo, Jessica
A1 Álvarez, Mar
A1 Baeza, Inmaculada
A1 Alda, Jose A.
A1 Martínez Cantarero, Carmen
A1 Parellada, Mara
A1 Sánchez, Bernardo
A1 Serna, Elena de la
A1 Giráldez, Marisa
A1 Arango López, Celso
AB Objectives: Despite known metabolic effects of second-generation antipsychotics (SGAs) on children and adolescents, comparative effects in youth with different diagnoses remain underreported. We compared differences in metabolic changes three months after starting treatment with SGAs in youth with bipolar disorder and with other psychotic and nonpsychotic disorders.Methods: Weight and metabolic differences among diagnostic groups before and three months after starting treatment with SGAs were compared in a naturalistic cohort of children and adolescents (14.9 ± 3.0 years) diagnosed with bipolar disorder (n = 31), other psychotic disorders (n = 29), and other nonpsychotic disorders (n = 30), with no (35.6%) or very little (6.6 ± 9.0 days) previous exposure to antipsychotics. Composite measurements of significant weight gain [weight increase ≥ 5% at three months or increase ≥ 0.5 in body mass index (BMI) z-score] and ‘risk for adverse health outcome’ (≥ 95th BMI percentile, or ≥ 85th BMI percentile plus presence of one other obesity-related complication) were included. SGAs (risperidone, olanzapine, and quetiapine) were prescribed in comparable proportion among groups.Results: Baseline weight and metabolic indices were not significantly different among diagnoses. Three months after starting treatment with SGAs, more than 70% patients had significant weight gain, BMI z-score increased in all diagnostic groups (p < 0.001 for all comparisons), total cholesterol increased in the bipolar (p = 0.02) and psychotic (p = 0.01) disorder groups, low-density lipoprotein cholesterol increased in the bipolar group (p = 0.02), and free T4 decreased in the psychotic disorder group (p = 0.05). More patients with bipolar disorder presented overweight plus ≥ 1 obesity-related complication at follow-up.Conclusions: There are early weight gain and metabolic changes across diagnoses in youth treated with SGAs
PB Wiley
SN 1398-5647
YR 2010
FD 2010-03-25
LK https://hdl.handle.net/20.500.14352/113020
UL https://hdl.handle.net/20.500.14352/113020
LA eng
NO Moreno C, Merchán-Naranjo J, Alvarez M, Baeza I, Alda JA, Martínez-Cantarero C, Parellada M, Sánchez B, de la Serna E, Giráldez M, Arango C. Metabolic effects of second-generation antipsychotics in bipolar youth: comparison with other psychotic and nonpsychotic diagnoses. Bipolar Disord. 2010 Mar;12(2):172-84. doi: 10.1111/j.1399-5618.2010.00797.x
NO Centro de Investigación Biomédica en Red de Salud Mental (España)
NO Ministerio de Ciencia e Innovación (España)
NO Instituto de Salud Carlos III (España)
NO Fundación Alicia Koplowitz
NO Caja Navarra
DS Docta Complutense
RD 12 abr 2025