RT Journal Article
T1 Clinical Practice Guideline of Spanish Society of Pneumology and Thoracic Surgery (SEPAR) on Pharmacological Treatment of Tobacco Dependence 2023
A1 Rábade-Castedo, Carlos
A1 Granda Orive, José Ignacio De
A1 Granda-Orive, José Ignacio
A1 Riesco-Miranda, Juan Antonio
A1 de Higes-Martínez, Eva
A1 Ramos-Pinedo, Ángela
A1 Cabrera-César, Eva
A1 Jiménez-Ruiz, Carlos Andrés
AB tIntroduction: There are multiple systematic reviews and meta-analyses on the efficacy and safety ofpharmacological treatments against nicotine dependence. However, there are few guidelines to answerfrequent questions asked by a clinician treating a smoker. Therefore, the aim of this paper is to facilitatethe treatment of tobacco addiction.Material and methods: 12 PICO questions are formulated from a GLOBAL PICO question: “Efficacy andsafety of pharmacological treatment of tobacco dependence”. A systematic review was carried out toanswer each of the questions and recommendations were made. The GRADE (Grading of Recommenda-tions, Assessment, Development and Evaluation) system was used to grade the certainty of the estimatedeffects and the strength of the recommendations.Results: Varenicline, nicotine replacement therapy (NRT), bupropion and cytisine are more effective thanplacebo. Varenicline and combined nicotine therapy are superior to the other therapies. In smokers withhigh dependence, a combination of drugs is recommended, being more effective those associations con-taining varenicline. Other optimization strategies with lower efficacy consist of increasing the doses, theduration, or retreat with varenicline. In specific populations varenicline or NRT is recommended. In hospi-talized, the treatment of choice is NRT. In pregnancy it is indicated to prioritize behavioral treatment. Thefinancing of smoking cessation treatments increases the number of smokers who quit smoking. There isno scientific evidence of the efficacy of pharmacological treatment of smoking cessation in adolescents.Conclusions: The answers to the 12 questions allow us to extract recommendations and algorithms forthe pharmacological treatment of tobacco dependence.
PB Elsevier
SN 0300-2896
YR 2023
FD 2023-10-31
LK https://hdl.handle.net/20.500.14352/113229
UL https://hdl.handle.net/20.500.14352/113229
LA eng
NO Rábade-Castedo C, de Granda-Orive JI, Riesco-Miranda JA, De Higes-Martínez E, Ramos-Pinedo Á, Cabrera-César E, Signes-Costa Miñana J, García Rueda M, Pastor-Esplá E, Jiménez-Ruiz CA. Clinical Practice Guideline of Spanish Society of Pneumology and Thoracic Surgery (SEPAR) on Pharmacological Treatment of Tobacco Dependence 2023. Arch Bronconeumol. 2023; 59: 651-61. doi: 10.1016/j.arbres.2023.07.024
NO None
DS Docta Complutense
RD 18 abr 2025