RT Journal Article
T1 Restoring pulmonary surfactant membranes and films at therespiratory surface
A1 Echaide Torreguitar, Mercedes
A1 Autilio, Chiara
A1 Arroyo, Raquel
A1 Pérez-Gil, Jesús
AB Pulmonary surfactant is a complex of lipids and proteins assembled and secreted by the alveolar epithelium into the thin layer of fluid coating the respiratory surface of lungs. There, surfactant forms interfacial films at the airwater interface, reducing dramatically surface tension and thus stabilizing the air-exposed interface to prevent alveolar collapse along respiratory mechanics. The absence or deficiency of surfactant produces severe lung pathologies. This review describes some of the most important surfactant-related pathologies, which are a cause of high morbidity and mortality in neonates and adults. The review also updates current therapeutic approaches pursuing restoration of surfactant operative films in diseased lungs, mainly through supplementation with exogenous clinical surfactant preparations. This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo V. Escribá.
PB Elsevier
SN 0006-3002
YR 2017
FD 2017-09
LK https://hdl.handle.net/20.500.14352/17997
UL https://hdl.handle.net/20.500.14352/17997
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Comunidad de Madrid
DS Docta Complutense
RD 12 abr 2025