RT Journal Article
T1 Synthesis and impact of neuroestradiol on hippocampal neuronal networks
A1 Azcoitia Elías, Iñigo
A1 Hernández Vivanco, Alicia
A1 Cano Adamuz, Nuria
A1 Méndez, Pablo
AB The production of estradiol within the brain, that is, neuroestradiol (nE2), is widely documented. nE2 deeply impacts adult brain physiology and synaptic plasticity. In the hippocampus, a region of the brain essential for cognitive function, multiple cellular sources, and targets of nE2 have been identified. The impact of estradiol in excitatory and inhibitory neurotransmission suggests a role for regulated nE2 synthesis in the coordination of the activity of different cellular elements of hippocampal network. Here, we review the role of nE2 in the physiology of the hippocampal circuits taking into account the cellular heterogeneity of the hippocampus. We aspire at expanding the consideration of neuron-derived estradiol as a neuromodulator of hippocampal network activities underlying cognition.
PB Elsevier
SN 2451-9650
YR 2022
FD 2022-02-20
LK https://hdl.handle.net/20.500.14352/71509
UL https://hdl.handle.net/20.500.14352/71509
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2022)
NO Ministerio de Ciencia e Innovación (MICINN)/Agencia Estatal de Investigación (AEI)
NO Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
DS Docta Complutense
RD 21 abr 2025