RT Journal Article
T1 Combined Hepatic and Pulmonary Metastasectomies From Colorectal Carcinoma. Data From the Prospective Spanish Registry 2008–2010
T2 Metastasectomías hepáticas y pulmonares combinadas de carcinoma colorrectal. Datos del registro prospectivo español 2008-2010
A1 Jarabo Sarceda, José Ramón
A1 Gómez Martínez, Ana María
A1 Calatayud Gastardi, Joaquín
A1 Fernández, Elena
A1 Pajuelo, Nuria
A1 Embún, Raúl
A1 Molins, Laureano
A1 Rivas, Juan
A1 Hernando Trancho, Florentino
A2 Villar Álvarez, Felipe
A2 Granda Orive, José Ignacio de
A2 Martínez García, Miguel Ángel
AB Introduction: Resection of both liver and lung metastases from colorectal carcinoma (CRC) is a standardof care in selected patients with oligometastatic disease. We present here the analysis of the subgroupof patients undergoing combined surgery from the Spanish Group of Surgery of Pulmonary Metastases(PM) from Colorectal Carcinoma (GECMP-CCR-SEPAR).Methods: We analyze characteristics, survival and prognostic factors of patients undergoing combinedresection from March-2008 to February-2010 and followed-up during at least 3 years, from the prospec-tive multicenter Spanish Registry.Results: A total of 138 patients from a whole series of 543 cases from 32 thoracic surgery units underwentboth procedures. Seventy-seven (43.8%) resected liver metastases were synchronic with colorectal tumor.Median disease specific survival (DSS) from first pulmonary metastasectomy was 48.9 months, beingthree and 5-year DSS 65.1% and 41.7%, respectively. From CRC-surgery median DSS was 97.2 months, with3 and 5-year DSS rates of 96.7% and 77%, respectively. Five-year DSS from pulmonary metastasectomywas 41.7% for patients with combined resection and 52.4% for those without hepatic involvement (P = .04).Differences disappeared when considering DSS from colorectal surgery. Carcinoembrionary antigen (CEA)before lung surgery over 10 mg/dl and bilateral PM were independent prognostic factors for survival(hazard ratio 2.4 and 2.5, respectively).Conclusions: Patients with resection of PM of CRC with history of resected hepatic metastases presentedsignificantly lower disease specific survival rates than those undergoing pulmonary metastasectomyalone. CEA before lung surgery and bilateral PM associated worse prognosis.
PB Elsevier
SN 0300-2896
YR 2018
FD 2018
LK https://hdl.handle.net/20.500.14352/93362
UL https://hdl.handle.net/20.500.14352/93362
LA eng
NO Jose R. Jarabo , Ana M. Gómez , Joaquín Calatayud, Carlos A. Fraile, Elena Fernández, Nuria Pajuelo, Raul Embún, Laureano Molins, Juan J. Rivas, Florentino Hernando on behalf of the Spanish Group of Lung Metastases of Colo-Rectal Cancer of the Spanish Society of Pneumology and Thoracic Surgery (GECMP-CCR-SEPAR). Título: Combined Hepatic and Pulmonary Metastasectomies From Colorectal Carcinoma. Data From the Prospective Spanish Registry 2008–2010 Revista/Libro: Arch Bronconeumol. 2018;54(4):189–197 https://doi.org/10.1016/j.arbres.2017.10.003
DS Docta Complutense
RD 4 abr 2025