RT Journal Article
T1 Functionalization of photosensitized silica nanoparticles for advanced photodynamic therapy of cancer
A1 Prieto Montero, Ruth
A1 Prieto Castañeda, Alejandro
A1 Katsumiti, Alberto
A1 Cajaraville, Miren P.
A1 Rodríguez Agarrabeitia, Antonia
A1 Ortiz García, María Josefa
A1 Martínez Martínez, Virginia
AB BODIPY dyes have recently attracted attention as potential photosensitizers. In this work, commercial and novel photosensitizers (PSs) based on BODIPY chromophores (haloBODIPYs and orthogonal dimers strategically designed with intense bands in the blue, green or red region of the visible spectra and high singlet oxygen production) were covalently linked to mesoporous silica nanoparticles (MSNs) further functionalized with PEG and folic acid (FA). MSNs approximately 50 nm in size with different functional groups were synthesized to allow multiple alternatives of PS-PEG-FA decoration of their external surface. Different combinations varying the type of PS (commercial Rose Bengal, Thionine and Chlorine e6 or custom-made BODIPY-based), the linkage design, and the length of PEG are detailed. All the nanosystems were physicochemically characterized (morphology, diameter, size distribution and PS loaded amount) and photophysically studied (absorption capacity, fluorescence efficiency, and singlet oxygen production) in suspension. For the most promising PS-PEG-FA silica nanoplatforms, the biocompatibility in dark conditions and the phototoxicity under suitable irradiation wavelengths (blue, green, or red) at regulated light doses (10–15 J/cm2) were compared with PSs free in solution in HeLa cells in vitro.
PB MDPI
SN 1422-0067
YR 2021
FD 2021-06-21
LK https://hdl.handle.net/20.500.14352/8376
UL https://hdl.handle.net/20.500.14352/8376
LA eng
NO Prieto Montero, R., Prieto Castañeda, A., Katsumiti, A. et al. «Functionalization of Photosensitized Silica Nanoparticles for Advanced Photodynamic Therapy of Cancer». International Journal of Molecular Sciences, vol. 22, n.o 12, junio de 2021, p. 6618. DOI.org (Crossref), https://doi.org/10.3390/ijms22126618.
NO Ministerio de Economía, Comercio y Empresa (España)
NO Gobierno Vasco
NO Universidad del País Vasco
DS Docta Complutense
RD 1 sept 2024