RT Journal Article
T1 Enzyme-Free Colorimetric Method for Fast Detection of PIK3CA Gene Mutation by Praseodymia Nanorods
A1 Jiang, Lei
A1 Wang, Meng
A1 Li, Youxun
A1 Zhang, Shuyuan
A1 Zhu, Xiudong
A1 Zhong, Junjie
A1 Sun, Jintao
A1 Tinoco Rivas, Miguel
A1 Chen, Xiaowei
AB The frequently mutated phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) gene is associated with multiple tumors and endocytosis of viruses. Identification of muted nucleotides at the hotspot can help in finding the susceptible people who are vulnerable to cancers and viruses. Herein, a simple enzyme-free colorimetric method is developed for the quick detection of PIK3CA gene mutations. The main mechanism lies in the dissimilar interactions between praseodymia nanorods and different nucleotides, as well as the underlying oxidase-mimicking characteristics of praseodymia. With rational designs of probes and processes, this method has great potential for expanded applications in the screening of mutations in other genes of interest.
SN 0003-2700
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/94752
UL https://hdl.handle.net/20.500.14352/94752
LA eng
NO Lei Jiang, Meng Wang, Youxun Li, Shuyuan Zhang, Xiudong Zhu, Junjie Zhong, Jingtao Sun, Miguel Tinoco, and Xiaowei Chen Analytical Chemistry 2023 95 (5), 2884-2892DOI: 10.1021/acs.analchem.2c04419
NO Natural Science Foundation of Shandong Province (China)
NO Fundamental Research Funds for the Central Universities (China)
NO Junta de Andalucía
NO Ministerio de Ciencia, Innovación y Universidades (España)
DS Docta Complutense
RD 7 abr 2025