RT Journal Article
T1 Orbitofrontal dysfunction related to depressive symptomatology in subjects with borderline personality disorder
A1 Díaz Marsa, Marina Francisca
A1 Carrasco Perera, José Luis
A1 López-Ibor Alcocer, María Inés
A1 Moratti, Stephan
A1 Montes, A.
A1 Ortiz Alonso, Tomás
A1 López-Ibor Aliño, Juan José
AB ObjectiveIn order to explore the relationships of fronto-limbic dysfunction with the clinical features of borderline personality disorder (BPD), the authors investigated brain electrophysiological activity in BPD patients following stimulation with emotionally arousing images.MethodsSeventeen non-medicated patients with borderline personality disorder were studied with magneto-encephalography. Regional cortical activities were obtained by minimum norm estimate (MNE) of steady-state visual evoked fields (ssVEFs). Linear regression models were conducted to explore clinical correlates of brain activity.ResultsAlthough no interaction group × picture category × brain region was found, a significant interaction group × brain region appeared for orbito-frontal cortex (OFC). BPD patients showed significantly reduced magnetocortical activity in left OFC across all picture categories (F = 26.4; p < .05; F = 31.4). Left OFC activity was inversely correlated with depression score in the BDI (r: − 0.48, p < 0.05), with score in the Cornell Dysthymia rating scale (r: − 0.52, p < 0.05) and with the number of criteria met for depressive personality disorder (r: − 0.44, p < 0.05). Left orbitofrontal activity was also inversely correlated with the global score in the GAF (r − 0.63, p < 0.01). No correlations were found between OFC activity and impulsivity or global severity of BPD symptoms.ConclusionsAbnormal functioning at orbitofrontal areas in BPD could be related to the presence of affective symptomatology and is associated with greater functional deterioration of patients.
PB Elsevier
SN 0165-0327
YR 2011
FD 2011-11
LK https://hdl.handle.net/20.500.14352/116911
UL https://hdl.handle.net/20.500.14352/116911
LA eng
NO Díaz-Marsá M, Carrasco JL, López-Ibor M, Moratti S, Montes A, Ortiz T, López-Ibor JJ. Orbitofrontal dysfunction related to depressive symptomatology in subjects with borderline personality disorder. J Affect Disord. 2011 Nov;134(1-3):410-5. doi: 10.1016/j.jad.2011.04.034
DS Docta Complutense
RD 6 abr 2025