RT Journal Article
T1 Evaluation of Anti-Neuroinflammatory Activity of Isatin Derivatives in Activated Microglia
A1 Cenalmor Molina, Alejandro
A1 Pascual Vega, Elena
A1 Gil-Manso, Sergio
A1 Correa-Rocha, Rafael
A1 Suárez Álvarez, José Ramón
A1 García-Álvarez, Isabel
AB Neuroinflammation plays a crucial role in the progression of Alzheimer’s disease and other neurodegenerative disorders. Overactivated microglia cause neurotoxicity and prolong the inflammatory response in many neuropathologies. In this study, we have synthesised a series of isatin derivatives to evaluate their anti-neuroinflammatory potential using lipopolysaccharide activated microglia as a cell model. We explored four different substitutions of the isatin moiety by testing their anti-neuroinflammatory activity on BV2 microglia cells. Based on the low cytotoxicity and the activity in reducing the release of nitric oxide, pro-inflammatory interleukin 6 and tumour necrosis factor α by microglial cells, the N1-alkylated compound 10 and the chlorinated 20 showed the best results at 25 µM. Taken together, the data suggest that 10 and 20 are promising lead compounds for developing new neuroprotective agents.
SN 1420-3049
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/100868
UL https://hdl.handle.net/20.500.14352/100868
LA eng
NO Cenalmor A, Pascual E, Gil-Manso S, Correa-Rocha R, Suárez JR, García-Álvarez I. Evaluation of Anti-Neuroinflammatory Activity of Isatin Derivatives in Activated Microglia. Molecules 2023;28:4882. https://doi.org/10.3390/molecules28124882.
NO Universidad Francisco de Vitoria
NO Fundación Banco Sabadell
NO Fundación Familia Alonso
DS Docta Complutense
RD 15 feb 2026