%0 Journal Article
%A Benede Ubieto, Raquel
%A Estévez Vázquez, Olga
%A Flores Perojo, Vicente
%A Macías Rodríguez, Ricardo U.
%A Ruiz Margáin, Astrid
%A Martínez Naves, Eduardo
%A Regueiro González-Barros, José Ramón
%A Avila, Matías A.
%A Trautwein, Christian
%A Bañares Cañizares, Rafael
%A Bosch, J.
%A Cubero Palero, Francisco Javier
%A Nevzorova, Yulia
%T Abnormal liver function test in patients infected with Coronavirus (SARS-CoV-2): a retrospective Single-Center Study from Spain
%D 2021
%U https://hdl.handle.net/20.500.14352/8508
%X The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and AST/ALT ratio were elevated above the Upper Limit of Normal (ULN) in 25.73%, 49.17%, 34.62%, 24.21%, 55.84% and 75% of patients, respectively. Interestingly, significant positive correlation between LDH levels and the AST/ALT ratio with disease outcome was found. Our data showed that SARS-CoV-2 virus infection leads to mild, but significant changes in serum markers of liver injury. The upregulated LDH levels as well as AST/ALT ratios upon admission may be used as additional diagnostic characteristic for COVID-19 patients.
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