RT Journal Article
T1 Abnormal liver function test in patients infected with Coronavirus (SARS-CoV-2): a retrospective Single-Center Study from Spain
A1 Benede Ubieto, Raquel
A1 Estévez Vázquez, Olga
A1 Flores Perojo, Vicente
A1 Macías Rodríguez, Ricardo U.
A1 Ruiz Margáin, Astrid
A1 Martínez Naves, Eduardo
A1 Regueiro González-Barros, José Ramón
A1 Avila, Matías A.
A1 Trautwein, Christian
A1 Bañares Cañizares, Rafael
A1 Bosch, J.
A1 Cubero Palero, Francisco Javier
A1 Nevzorova, Yulia
AB The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and AST/ALT ratio were elevated above the Upper Limit of Normal (ULN) in 25.73%, 49.17%, 34.62%, 24.21%, 55.84% and 75% of patients, respectively. Interestingly, significant positive correlation between LDH levels and the AST/ALT ratio with disease outcome was found. Our data showed that SARS-CoV-2 virus infection leads to mild, but significant changes in serum markers of liver injury. The upregulated LDH levels as well as AST/ALT ratios upon admission may be used as additional diagnostic characteristic for COVID-19 patients.
PB MDPI
YR 2021
FD 2021-03-03
LK https://hdl.handle.net/20.500.14352/8508
UL https://hdl.handle.net/20.500.14352/8508
LA eng
NO Benedé Ubieto, R., Estévez Vázquez, O., Flores Perojo, V. et al. «Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain». Journal of Clinical Medicine, vol. 10, n.o 5, marzo de 2021, p. 1039. DOI.org (Crossref), https://doi.org/10.3390/jcm10051039.
NO Ministerio de Economía, Comercio y Empresa (España)
NO Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional
NO Programa Ramón y Cajal
NO Universidad Complutense de Madrid/Banco de Santander
NO Gobierno de Navarra
NO German Research Foundation
DS Docta Complutense
RD 10 abr 2025