RT Journal Article
T1 Analysis of craniocervical abnormalities in osteogenesis imperfecta during growth
A1 Nova García, Manuel Joaquín De
A1 García de Sola, Rafael
A1 Burgueño Torres, Laura
AB Osteogenesis Imperfecta (OI) is a genetic disease characterized by osteopenia and bone fragility in which the craniocervical junction is also affected. This is of special relevance due to the high prevalence in anomalies described in the literature as follows: basilar invagination, basilar impression, and platybasia. Methods. We analyzed 19 lateral skull radiographs and 14 magnetic resonance images (MRIs) of 28 patients with OI in which eight linear and five angular measurementswere plotted to determine the existence of craniocervical junction anomalies and compare them with 38 lateral skull radiographs and 28 MRIs performed on age-matched healthy controls. Results. From the reference values obtained from the control sample for each age group, we established the limit value at which pathology could be suspected. Some of the variables studied showed a clear trend associated with growth. More than half of the patients (60.71%) presented an anomaly in the skull base. Conclusions. According to the diagnostic criteria used and taking +2.5 SD as the limit value, 10.71% of the patients had basilar invagination, 35.71% had basilar impression, and 39.29% had platybasia, the latter being the most common finding
PB MDPI
SN 2076-3417
YR 2024
FD 2024-02-18
LK https://hdl.handle.net/20.500.14352/102394
UL https://hdl.handle.net/20.500.14352/102394
LA eng
NO De Nova-García MJ, Sola RG, Burgueño-Torres L. Analysis of Craniocervical Abnormalities in Osteogenesis Imperfecta during Growth. Applied Sciences. 2024; 14(4):1640
DS Docta Complutense
RD 19 jul 2024