RT Journal Article
T1 The Conducted Vasomotor Response: Function, Biophysical Basis, and Pharmacological Control
A1 Welsh, Donald G.
A1 Tran, Cam Ha T.
A1 Hald, Bjorn O.
A1 Sancho González, María
AB Arterial tone is coordinated among vessel segments to optimize nutrient transport and organ function. Coordinated vasomotor activity is remarkable to observe and depends on stimuli, sparsely generated in tissue, eliciting electrical responses that conduct lengthwise among electrically coupled vascular cells. The conducted response is the focus of this topical review, and in this regard, the authors highlight literature that advances an appreciation of functional significance, cellular mechanisms, and biophysical principles. Of particular note, this review stresses that conduction is enabled by a defined pattern of charge movement along the arterial wall as set by three key parameters (tissue structure, gap junctional resistivity, and ion channel activity). The impact of disease on conduction is carefully discussed, as are potential strategies to restore this key biological response and, along with it, the match of blood flow delivery with tissue energetic demand.
PB Annual Reviews
SN 0362-1642
YR 2018
FD 2018-01-06
LK https://hdl.handle.net/20.500.14352/109660
UL https://hdl.handle.net/20.500.14352/109660
LA eng
NO Welsh DG, Tran CHT, Hald BO, Sancho M. The Conducted Vasomotor Response: Function, Biophysical Basis, and Pharmacological Control. Annu Rev Pharmacol Toxicol. 58:391-410. doi: 10.1146/annurev-pharmtox-010617-052623.
DS Docta Complutense
RD 4 abr 2025