RT Journal Article
T1 Understanding inbreeding depression, purging, andgenetic rescue
A1 Hedrick, P. W.
A1 García-Dorado, Aurora
AB Inbreeding depression, the reduction of fitness caused by inbreeding, is a nearly universal phenomenon that depends on past mutation, selection, and genetic drift. Recent estimates suggest that its impact on individual fitness is even greater than previously thought. Genomic information is contributing to its detection and can enlighten important aspects of its genetic architecture. In natural populations, purging and genetic rescue mitigate fitness decline during inbreeding periods, and might be critical to population survival, thus, both mechanisms should be considered when assessing extinction risks. However, deliberate purging and genetic rescue involve considerable risk in the short and medium term, so that neither appears to be a panacea against high inbreeding depression.
PB Elsevier
SN 0169-5347, ESSN: 1872-8383
YR 2016
FD 2016-12
LK https://hdl.handle.net/20.500.14352/17819
UL https://hdl.handle.net/20.500.14352/17819
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 10 jun 2026