RT Journal Article
T1 The Adrenal Medulla Modulates Mechanical Allodynia in a Rat Model of Neuropathic Pain
A1 Arribas Blázquez, Marina
A1 Olivos Ore, Luis Alcides
A1 Barahona Gomáriz, María Victoria
A1 Wojnicz, Aneta
A1 Pascual, Ricardo De
A1 Sánchez De La Muela, María Mercedes
A1 García García, Antonio
A1 Rodríguez Artalejo, Antonio
AB We have investigated whether the stress response mediated by the adrenal medulla in rats subjected to chronic constriction injury of the sciatic nerve (CCI) modulates their nocifensive behavior. Treatment with SK29661 (300 mg/kg; intraperitoneal (I.P.)), a selective inhibitor of phenylethanolamine N-methyltransferase (PNMT) that converts noradrenaline (NA) into adrenaline (A), fully reverted mechanical allodynia in the injured hind paw without affecting mechanical sensitivity in the contralateral paw. The effect was fast and reversible and was associated with a decrease in the A to NA ratio (A/NA) in the adrenal gland and circulating blood, an A/NA that was elevated by CCI. 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (SKF29661) did not affect exocytosis evoked by Ca2+ entry as well as major ionic conductances (voltage-gated Na+, Ca2+, and K+ channels, nicotinic acetylcholine receptors) involved in stimulus-secretion coupling in chromaffin cells, suggesting that it acted by changing the relative content of the two adrenal catecholamines. Denervation of the adrenal medulla by surgical splanchnectomy attenuated mechanical allodynia in neuropathic animals, hence confirming the involvement of the adrenal medulla in the pathophysiology of the CCI model. Inhibition of PNMT appears to be an effective and probably safe way to modulate adrenal medulla activity and, in turn, to alleviate pain secondary to the injury of a peripheral nerve.
PB MDPI
SN 1661-6596
YR 2020
FD 2020-11-06
LK https://hdl.handle.net/20.500.14352/91764
UL https://hdl.handle.net/20.500.14352/91764
LA eng
NO Universidad Complutense de Madrid
NO Ministerio de Ciencia e Innovación
DS Docta Complutense
RD 30 dic 2025